Publications

Publications by year

2023

• Harker JA, Lloyd CM, 2023, T helper 2 cells in asthma., J Exp Med, Vol: 220
• Granell R, Curtin JA, Haider S, Kitaba NT, Mathie SA, Gregory LG, Yates LL, Tutino M, Hankinson J, Perretti M, Vonk JM, Arshad HS, Cullinan P, Fontanella S, Roberts GC, Koppelman GH, Simpson A, Turner SW, Murray CS, Lloyd CM, Holloway JW, Custovic A, UNICORN and Breathing Together Investigators et al., 2023, A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing., Elife, Vol: 12
• Saglani S, Yates L, Lloyd CM, 2023, Immunoregulation of asthma by type 2 cytokine therapies: Treatments for all ages?, EUROPEAN JOURNAL OF IMMUNOLOGY, ISSN: 0014-2980
• Joulia, R., Puttur, F., Stölting, H., Entwistle, L.J., Voitovich, A., Al-Sahaf, M., Bonner, K., Scotney, E., Molyneaux, P.L., Hewitt, R.J., Walker, S.A., Yates, L.L., Saglani, S., Lloyd, C.M. (2023) Adventitial mast cell activation disrupts endothelial cell/pericyte interactions during early life allergic asthma. bioRxiv 2023.03.07.529253. 
• Puttur F, Lloyd CM, 2023, Breathing easy: Dopamine quenches the ILC2 flame, IMMUNITY, Vol: 56, Pages: 229-231, ISSN: 1074-7613

2022

• Hewitt RJ, Puttur F, Gaboriau DCA, Fercoq F, Fresquet M, Traves WJ et al. Lung extracellular matrix modulates KRT5⁺ basal cell activity in pulmonary fibrosis. bioRxiv 2022: 2022.2012.2016.520808.
• Pyle CJ, Patel DF, Peiró T, Joulia R, Grabiec AM, Hussell T, Tavernier G, Simpson A, Pease J, Harker JA, Lloyd CM, Snelgrove RJ. Matrix Metalloproteinase-12 Supports Pulmonary B Cell Follicle Formation and Local Antibody Responses During Asthma. Am J Respir Crit Care Med. 2022 Dec 1;206(11):1424-1428. doi: 10.1164/rccm.202109-2082LE. PMID: 35944138.
• Stölting H, Baillon L, Frise R, Bonner K, Hewitt RJ, Molyneaux PL, Gore ML; Breathing Together Consortium, Barclay WS, Saglani S, Lloyd CM. Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1. Mucosal Immunol. 2022 Jul 15:1–12. doi: 10.1038/s41385-022-00545-4. Epub ahead of print. PMID: 35840680; PMCID: PMC9284972.
• Rahimi RA, Cho JL, Jakubzick CV, Khader SA, Lambrecht BN, Lloyd CM, Molofsky AB, Talbot S, Bonham CA, Drake WP, Sperling AI, Singer BD. Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 Jul;67(1):e1-18. doi: 10.1165/rcmb.2022-0167ST. PMID: 35776495; PMCID: PMC9273224.
• Stölting H, Lloyd CM. Pseudomonas aeruginosa: a pathogen making itself at home. Trends Immunol. 2022 Jul;43(7):497-499. doi: 10.1016/j.it.2022.05.002. Epub 2022 May 30. PMID: 35654640.
• Pattaroni C, Macowan M, Chatzis R, Daunt C, Custovic A, Shields MD, Power UF, Grigg J, Roberts G, Ghazal P, Schwarze J, Gore M, Turner S, Bush A, Saglani S, Lloyd CM, Marsland BJ. Early life inter-kingdom interactions shape the immunological environment of the airways. Microbiome. 2022 Feb 21;10(1):34. doi: 10.1186/s40168-021-01201-y. PMID: 35189979; PMCID: PMC8862481.
• Vijayakumar B, Boustani K, Ogger PP, Papadaki A,  Tonkin J, Orton CM, Ghai P,  Suveizdyte K,  Hewitt RJ, Desai SR, Devaraj A,  Snelgrove RJ,  Molyneaux PL, Garner JL, Peters JE, Shah PL, Lloyd CM,  Harker JA. Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVD-19 respiratory disease. Immunity 2022 Jan 26. doi.org/10.1016/j.immuni.2022.01.017.

2021

• McErlean P, Bell CG, Hewitt RJ, Busharat Z, Ogger PP, Ghai P, Albers GJ, Calamita E, Kingston S, Molyneaux PL, Beck S, Lloyd CM, Maher TM, Byrne AJ. DNA Methylome Alterations are Associated with Airway Macrophage Differentiation and Phenotype During Lung Fibrosis. Am J Respir Crit Care Med. 2021 Jul 19. doi: 10.1164/rccm.202101-0004OC. Epub ahead of print. PMID: 34280322.
• Harker JA, Lloyd CM. Overlapping and distinct features of viral and allergen immunity in the human lung. Immunity. 2021 Apr 13;54(4):617-631. doi: 10.1016/j.immuni.2021.03.010. PMID: 33852829.
• Branchett WJ, Walker SA, Lloyd CM. Experimental Mouse Models of Asthma and Analysis of CD4 T Cells. Methods Mol Biol. 2021;2285:329-348. doi: 10.1007/978-1-0716-1311-5_25. PMID: 33928563.

• Branchett WJ, Cook J, Oliver RA, Bruno N, Walker SA, Stölting H, Mack M, O’Garra A, Saglani S, Lloyd CM. Airway macrophage-intrinsic TGF-β1 regulates pulmonary immunity during early-life allergen exposure. J Allergy Clin Immunol. 2021 Feb 9:S0091-6749(21)00173-1. doi: 10.1016/j.jaci.2021.01.026. Epub ahead of print. PMID: 33571538.

• Hewitt RJ, Lloyd CM. Regulation of immune responses by the airway epithelial cell landscape. Nat Rev Immunol. 2021 Jan 13:1–16. doi: 10.1038/s41577-020-00477-9. Epub ahead of print. PMID: 33442032; PMCID: PMC7804588.
• Albers GJ, Iwasaki J, McErlean P, Ogger PP, Ghai P, Khoyratty TE, Udalova IA, Lloyd CM, Byrne AJ. IRF5 regulates airway macrophage metabolic responses. Clin Exp Immunol. 2021 Jan 10. doi: 10.1111/cei.13573. Epub ahead of print. PMID: 33423291.

2020

• Ogger PP, Albers GJ, Hewitt RJ, O’Sullivan BJ, Powell JE, Calamita E, Ghai P, Walker SA, McErlean P, Saunders P, Kingston S, Molyneaux PL, Halket JM, Gray R, Chambers DC, Maher TM, Lloyd CM, Byrne AJ. Itaconate controls the severity of pulmonary fibrosis. Sci Immunol. 2020 Oct 23;5(52):eabc1884. doi: 10.1126/sciimmunol.abc1884. PMID: 33097591.
• Ubags NDJ, Alejandre Alcazar MA, Kallapur SG, Knapp S, Lanone S, Lloyd CM, Morty RE, Pattaroni C, Reynaert NL, Rottier RJ, Smits HH, de Steenhuijsen Piters WAA, Strickland DH, Collins JJP. Early origins of lung disease: towards an interdisciplinary approach. Eur Respir Rev. 2020 Oct 1;29(157):200191. doi: 10.1183/16000617.0191-2020. PMID: 33004528.
• Invernizzi R, Wu BG, Barnett J, et al. The Respiratory Microbiome in Chronic Hypersensitivity Pneumonitis is Distinct from that of Idiopathic Pulmonary Fibrosis [published online ahead of print, 2020 Jul 21]. Am J Respir Crit Care Med. 2020;10.1164/rccm.202002-0460OC. doi:10.1164/rccm.202002-0460OC
• Branchett WJ, O’Garra A, Lloyd CM. Transcriptomic analysis reveals diverse gene expression changes in airway macrophages during experimental allergic airway disease. Wellcome Open Res. 2020;5:101. Published 2020 Jun 22. doi:10.12688/wellcomeopenres.15875.2
• Porsbjerg CM, Sverrild A, Lloyd CM, Menzies-Gow AN, Bel EH. Anti-alarmins in asthma: targeting the airway epithelium with next-generation biologics [published online ahead of print, 2020 Jun 25]. Eur Respir J. 2020;2000260. doi:10.1183/13993003.00260-2020
• Durrington HJ, Krakowiak K, Meijer P, et al. Circadian asthma airway responses are gated by REV-ERBα [published online ahead of print, 2020 Jun 25]. Eur Respir J. 2020;1902407. doi:10.1183/13993003.02407-2019
• Andersson CK, Iwasaki J, Cook J, et al. Impaired airway epithelial cell wound-healing capacity is associated with airway remodelling following RSV infection in severe preschool wheeze [published online ahead of print, 2020 Jun 23]. Allergy. 2020;10.1111/all.14466. doi:10.1111/all.14466
• Invernizzi R, Lloyd CM, Molyneaux PL. Respiratory microbiome and epithelial interactions shape immunity in the lungs. Immunology. 2020;160(2):171-182. doi:10.1111/imm.13195
• Entwistle LJ, Puttur F, Gregory LG, Lloyd CM. Group 2 ILC Functional Assays in Allergic Airway Inflammation. Methods Mol Biol. 2020;2121:99-114. doi:10.1007/978-1-0716-0338-3_10
• Entwistle LJ, Gregory LG, Oliver RA, Branchett WJ, Puttur F, Lloyd CM. Pulmonary Group 2 Innate Lymphoid Cell Phenotype Is Context Specific: Determining the Effect of Strain, Location, and Stimuli. Front Immunol. 2020;10:3114. Published 2020 Jan 22. doi:10.3389/fimmu.2019.03114
• Invernizzi R, Barnett J, Rawal B, et al. Bacterial burden in the lower airways predicts disease progression in idiopathic pulmonary fibrosis and is independent of radiological disease extent. Eur Respir J. 2020;55(4):1901519. Published 2020 Apr 3. doi:10.1183/13993003.01519-2019
• Byrne AJ, Powell JE, O’Sullivan BJ, Ogger PP, Hoffland A, Cook J, Bonner KL, Hewitt RJ, Wolf S, Ghai P, Walker SA, Lukowski SW, Molyneaux PL, Saglani S, Chambers DC, Maher TM, Lloyd CM. Dynamics of human monocytes and airway macrophages during healthy aging and after transplant. J Exp Med. 2020 Mar 2;217(3). pii: e20191236. doi: 10.1084/jem.20191236. PubMed PMID: 31917836.

2019

• Abeler-Dörner L, Laing AG, Lorenc A, Ushakov DS, Clare S, Speak AO, Duque-Correa MA, White JK, Ramirez-Solis R, Saran N, Bull KR, Morón B, Iwasaki J, Barton PR, Caetano S, Hng KI, Cambridge E, Forman S, Crockford TL, Griffiths M, Kane L, Harcourt K, Brandt C, Notley G, Babalola KO, Warren J, Mason JC, Meeniga  A, Karp NA, Melvin D, Cawthorne E, Weinrick B, Rahim A, Drissler S, Meskas J, Yue A, Lux M, Song-Zhao GX, Chan A, Ballesteros Reviriego C, Abeler J, Wilson H, Przemska-Kosicka A, Edmans M, Strevens N, Pasztorek M, Meehan TF, Powrie F, Brinkman R, Dougan G, Jacobs W Jr, Lloyd CM, Cornall RJ, Maloy KJ, Grencis RK, Griffiths GM, Adams DJ, Hayday AC. High-throughput phenotyping reveals expansive  genetic and structural underpinnings of immune variation. Nat Immunol. 2020 Jan;21(1):86-100. doi: 10.1038/s41590-019-0549-0. Epub 2019 Dec 16. 
• Foster WS, Grime CJ, Tan HL, Williams GS, Robinson MJ, Carlesso G, Saglani S, Lloyd CM, Harker JA. Enhanced frequency and function of follicular T cells in the tonsils of house dust mite sensitized children. Allergy. 2019 Dec 14. doi: 10.1111/all.14150. 
• Patel DF, Peiró T, Bruno N, Vuononvirta J, Akthar S, Puttur F, Pyle CJ, Suveizdytė K, Walker SA, Singanayagam A, Carlin LM, Gregory LG, Lloyd CM,Snelgrove RJ. Neutrophils restrain allergic airway inflammation by limiting ILC2  function and monocyte-dendritic cell antigen presentation. Sci Immunol. 2019 Nov  8;4(41). pii: eaax7006. doi: 10.1126/sciimmunol.aax7006. 
• Branchett WJ, Stölting H, Oliver RA, Walker SA, Puttur F, Gregory LG, Gabryšová L, Wilson MS, O’Garra A, Lloyd CM. A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma. J Allergy Clin Immunol. 2019 Aug 22. pii: S0091-6749(19)31079-6. doi:10.1016/j.jaci.2019.08.006.
• Lloyd CM, Saglani S. Opening the Window of Immune Opportunity: Treating Childhood Asthma. Trends Immunol. 2019 Sep;40(9):786-798. doi: 10.1016/j.it.2019.07.004.
• Invernizzi R, Molyneaux PL. The contribution of infection and the respiratory microbiome in acute exacerbations of idiopathic pulmonary fibrosis. Eur Respir Rev 2019; 28: 190045. doi: 10/1183/16000617.0045-2019
• Singhania A, Graham CM, Gabrysova L, Moreira-Teixeira L, Stavropoulos E, Pitt JM, Chakravarty P, Warnatsch A, Branchett WJ, Conejero L, Lin JW, Davidson S, Wilson MS, Bancroft G, Langhorne J, Frickel E, Sesay AK, Priestnall SL, Herbert E, Ioannou M, Wang Q, Humphreys IR, Dodd J, Openshaw PJM, Mayer-Barber KD, Jankovic D, Sher A, Lloyd CM, Baldwin N, Chaussabel D, Papayannopoulos V, Wack A, Banchereau JF, Pascual VM, O’Garra A. Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nat Commun. 2019 Jun 28;10(1): 2887. doi: 10.1038/s4167-019-10601-6. 
• Turnbull AR, Pyle CJ, Patel DF, Jackson PL, Hilliard TN, Regamey N, Tan HL, Brown S, Thursfield R, Short C, Mc Fie M, Alton EWFW, Gaggar A, Blalock JE, Lloyd CM, Bush A, Davies JC, Snelgrove RJ. Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis .J Cyst Fibros. 2019 Jun 5. pii: S1569-1993(19)30769-6. doi: 10.1016/j.jcf.2019.05.017.
• Puttur F, Denney L, Gregory LG, Vuononvirta J, Oliver R, Entwistle LJ, Walker SA, Headley MB, McGhee EJ, Pease JE, Krummel MF, Carlin LM, Lloyd CM. Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans. Sci Immunol. 2019 Jun 7;4(36). pii: eaav7638. doi: 10.1126/sciimmunol.aav7638.
• Nagakumar P, Puttur F, Gregory LG, Denney L, Fleming L, Bush A, Lloyd CM, Saglani S. Pulmonary type2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids. Eur Respir J. 2019 Jun 4. pii: 1801809. doi: 10.1183/13993003.01809-2018. 
• Allden SJ, Ogger PP, Ghai P, McErlean P, Hewitt R, Toshner R, Walker SA, Saunders P, Kingston S, Molyneaux PL, Maher TM, Lloyd CM, Byrne AJ. The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. doi: 10.1164/rccm.201809-1775OC.
• Branchett WJ, Lloyd CM. Regulatory cytokine function in the respiratory tract. Mucosal Immunol. 2019 May;12(3):589-600. doi: 10.1038/s41385-019-0158-0.
• Puttur F, Gregory LG, Lloyd CM. Airway macrophages as the guardians of tissue  repair in the lung. Immunol Cell Biol. 2019 Mar;97(3):246-257. doi: 10.1111/imcb.12235.
• Davies ER, Denney L, Wandel M, Lloyd CM, Davies DE, Haitchi HM. Regulation of ectodomain shedding of ADAM33 in vitro and in vivo. J Allergy Clin Immunol. doi: 10.1016/j.jaci.2019.01.026.

2018

• Robinson PFM, Pattaroni C, Cook J, Gregory L, Alonso AM, Fleming LJ, Lloyd CM, Bush A, Marsland BJ, Saglani S.  Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze. (2018) J Allergy Clin Immunol. doi: 10.1016/j.jaci.2018.12.985.
• Zhang Y, Willis-Owen SAG, Spiegel S, Lloyd CM, Moffatt MF, Cookson WOCM. The ORMDL3 Asthma Gene Regulates ICAM1 and has Multiple Effects on Cellular Inflammation. (2018) Am J Respir Crit Care Med . doi: 10.1164/rccm.201803-0438OC.
• Uwadiae FI, Pyle CJ, Walker SA, Lloyd CM, Harker JA. Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease. (2018) Allergy.  doi: 10.1111/all.13602.
• Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ,
• Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA,
• Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM. Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13(+)CD4(+) T cells. (2018) Science Immunol., 7;3(27). doi: 10.1126/sciimmunol.aan4128.
• Turner S, Custovic A, Ghazal P, Grigg J, Gore M, Henderson J, Lloyd CM,
• Marsland B, Power UF, Roberts G, Saglani S, Schwarze J, Shields M, Bush A.
• Pulmonary epithelial barrier and immunological functions at birth and in early life – key determinants of the development of asthma?  A description of the protocol for the Breathing Together study. Wellcome Open Res. (2018) doi: 10.12688/wellcomeopenres.14489.1.
• Snelgrove, R.J., Patel, D.F., Patel, T., Lloyd, C.M. The enigmatic role of the neutrophil in asthma: Friend, foe or indifferent? (2018) Clinical and Experimental Allergy, 48 (10), pp. 1275-1285. DOI: 10.1111/cea.13191
• Patel, D.F., Peiró, T., Shoemark, A., Akthar, S., Walker, S.A., Grabiec, A.M., Jackson, P.L., Hussell, T., Gaggar, A., Xu, X., Trevor, J.L., Li, J., Steele, C., Tavernier, G., Edwin Blalock, J., Niven, R.M., Gregory, L.G., Simpson, A., Lloyd, C.M., Snelgrove, R.J.An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness(2018) Science Translational Medicine, 10 (455) DOI: 10.1126/scitranslmed.aaq0693
• Lloyd CM, Snelgrove RJ. Type 2 immunity: Expanding our view. (2018) Sci Immunol. doi: 10.1126/sciimmunol.aat1604.
• Snelgrove, R.J., Lloyd, C.M. Tasting type 2 inflammation in the airways (2018) Journal of Allergy and Clinical Immunology, 142 (2), pp. 403-404. DOI: 10.1016/j.jaci.2018.06.009
• Lloyd, C.M., Harker, J.A. Epigenetic control of interleukin-9 in asthma(2018) New England Journal of Medicine, 379 (1), pp. 87-89. DOI: 10.1056/NEJMcibr1803610 
• Meiners, S., Lloyd, C., Chambers, R.C. Cell–matrix interactions in lung disease and regeneration: ERS lung science conference 2018 report (2018) European Respiratory Review, 27 (148) DOI: 10.1183/16000617.0040-2018
• Peiró, T., Patel, D.F., Akthar, S., Gregory, L.G., Pyle, C.J., Harker, J.A., Birrell, M.A., Lloyd, C.M., Snelgrove, R.J. Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection (2018) Thorax, 73 (6), pp. 546-556. DOI: 10.1136/thoraxjnl-2017-210010
• Saglani, S., Lloyd, C.M. The Immunopathogenesis of Asthma (2018) Kendig’s Disorders of the Respiratory Tract in Children, pp. 665-676 DOI: 10.1016/B978-0-323-44887-1.00043-2
• Saglani, S., Lloyd, C.M., Bush, A. Biology and Assessment of Airway Inflammation (2018) Kendig’s Disorders of the Respiratory Tract in Children, pp. 101-119 DOI: 10.1016/B978-0-323-44887-1.00007-9
• Denney, L., Branchett, W., Gregory, L.G., Oliver, R.A., Lloyd, C.M.Epithelial-derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection (2018) Mucosal Immunology, 11 (2), pp. 523-535. DOI: 10.1038/mi.2017.77
• Pavord, I.D., Beasley, R., Agusti, A., Anderson, G.P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F.M., Fahy, J.V., Frey, U., Gibson, P., Heaney, L.G., Holt, P.G., Humbert, M., Lloyd, C.M., Marks, G., Martinez, F.D., Sly, P.D., von Mutius, E., Wenzel, S., Zar, H.J., Bush, A. After asthma: redefining airways diseases (2018) The Lancet, 391 (10118), pp. 350-400. DOI: 10.1016/S0140-6736(17)30879-6
• Zhang, Y., Poobalasingam, T., Yates, L.L., Walker, S.A., Taylor, M.S., Chessum, L., Harrison, J., Tsaprouni, L., Adcock, I.M., Lloyd, C.M., Cookson, W.O., Moffatt, M.F., Dean, C.H.Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma (2018) DMM Disease Models and Mechanisms, 11 (1) DOI: 10.1242/dmm.031369

2017

• Dean, C.H., Lloyd, C.M. Lung Alveolar Repair: Not All Cells Are Equal (2017) Trends in Molecular Medicine, 23 (10), pp. 871-873. DOI: 10.1016/j.molmed.2017.08.009
• Snelgrove, R.J., Lloyd, C.M. An NLRP3, IL-1β, neutrophil axis in the respiratory tract leaves you breathless(2017) American Journal of Respiratory and Critical Care Medicine, 196 (3), pp. 253-254. DOI: 10.1164/rccm.201703-0483ED
• Lloyd, C.M., Saglani, S. Development of allergic immunity in early life (2017) Immunological Reviews, 278 (1), pp. 101-115. DOI: 10.1111/imr.12562
• Weiss, G., Lai, C., Fife, M.E., Grabiec, A.M., Tildy, B., Snelgrove, R.J., Xin, G., Lloyd, C.M., Hussell, T. Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors(2017) Mucosal Immunology, 10 (4), pp. 1021-1030. DOI: 10.1038/mi.2016.104
• Andersson, C.K., Adams, A., Nagakumar, P., Bossley, C., Gupta, A., De Vries, D., Adnan, A., Bush, A., Saglani, S., Lloyd, C.M. Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function(2017) Journal of Allergy and Clinical Immunology, 139 (6), pp. 1819-1829 DOI: 10.1016/j.jaci.2016.09.022
• Byrne, A.J., Weiss, M., Mathie, S.A., Walker, S.A., Eames, H.L., Saliba, D., Lloyd, C.M., Udalova, I.A. A critical role for IRF5 in regulating allergic airway inflammation(2017) Mucosal Immunology, 10 (3), pp. 716-726. DOI: 10.1038/mi.2016.92
• Löser, S., Gregory, L.G., Zhang, Y., Schaefer, K., Walker, S.A., Buckley, J., Denney, L., Dean, C.H., Cookson, W.O.C., Moffatt, M.F., Lloyd, C.M. Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease (2017) Journal of Allergy and Clinical Immunology, 139 (5), pp. 1496-1507 DOI: 10.1016/j.jaci.2016.07.033
• Edwards, M.R., Saglani, S., Schwarze, J., Skevaki, C., Smith, J.A., Ainsworth, B., Almond, M., Andreakos, E., Belvisi, M.G., Chung, K.F., Cookson, W., Cullinan, P., Hawrylowicz, C., Lommatzsch, M., Jackson, D., Lutter, R., Marsland, B., Moffatt, M., Thomas, M., Virchow, J.C., Xanthou, G., Edwards, J., Walker, S., Johnston, S.L., Adcock, I., Akdis, C., Bel, E., Bousquet, J., Ten Brinke, A., Brusselle, G., Dáhlen, S.-E., Djukanovic, R., Gaga, M., Garcia-Marcos, L., Hiemstra, P., Heffler, E., Holgate, S., Kupczyk, M., Lloyd, C., Lucas, J., Magnan, A., Martin, T., Myles, D., Page, C., Palkonen, S., Papadopoulos, N., Papi, A., Powell, P., Riley, J., Sayers, I., Spanevello, A., Sterk, P., Xepapadaki, P., Wheelock, .C. Addressing unmet needs in understanding asthma mechanisms (2017) European Respiratory Journal, 49 (5) DOI: 10.1183/13993003.02448-2016
• Lloyd, C.M., Marsland, B.J. Lung Homeostasis: Influence of Age, Microbes, and the Immune System (2017) Immunity, 46 (4), pp. 549-561. DOI: 10.1016/j.immuni.2017.04.005
• Poobalasingam, T., Yates, L.L., Walker, S.A., Pereira, M., Gross, N.Y., Ali, A., Kolatsi-Joannou, M., Jarvelin, M.-R., Pekkanen, J., Papakrivopoulou, E., Long, D.A., Griffiths, M., Wagner, D., Konigshoff, M., Hind, M., Minelli, C., Lloyd, C.M., Dean, C.H. Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair(2017) DMM Disease Models and Mechanisms, 10 (4), pp. 409-423. DOI: 10.1242/dmm.028175
• Low, C.M., Akthar, S., Patel, D.F., Löser, S., Wong, C.-T., Jackson, P.L., Blalock, J.E., Hare, S.A., Lloyd, C.M., Snelgrove, R.J. The development of novel LTA4 H modulators to selectively target LTB4 generation (2017) Scientific Reports, 7 DOI: 10.1038/srep44449

2016

• Byrne, A.J., Maher, T.M., Lloyd, C.M. Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease? (2016) Trends in Molecular Medicine, 22 (4), pp. 303-316. DOI: 10.1016/j.molmed.2016.02.004
• Nagakumar, P., Denney, L., Fleming, L., Bush, A., Lloyd, C.M., Saglani, S. Type 2 innate lymphoid cells in induced sputum from children with severe asthma (2016) Journal of Allergy and Clinical Immunology, 137 (2), pp. 624-626. DOI: 10.1016/j.jaci.2015.06.038
• Lloyd, C.M., Harker, J.A. Location, Location, Location: Localized Memory Cells Take Residence in the Allergic Lung (2016) Immunity, 44 (1), pp. 13-15. DOI: 10.1016/j.immuni.2015.12.012
• Saglani, S., Lloyd, C.M. Prostacyclin as a potential novel means to manipulate type 2 innate lymphoid cell function(2016) American Journal of Respiratory and Critical Care Medicine, 193 (1), pp. 2-4. DOI: 10.1164/rccm.201509-1773ED

2015

• Saglani, S., Lloyd, C.M. Novel concepts in airway inflammation and remodelling in asthma (2015) European Respiratory Journal, 46 (6), pp. 1796-1804. DOI: 10.1183/13993003.01196-2014
• Byrne, A.J., Mathie, S.A., Gregory, L.G., Lloyd, C.M. Pulmonary macrophages: Key players in the innate defence of the airways (2015) Thorax, 70 (12), pp. 1189-1196. DOI: 10.1136/thoraxjnl-2015-207020
• Akthar, S., Patel, D.F., Beale, R.C., Peiró, T., Xu, X., Gaggar, A., Jackson, P.L., Blalock, J.E., Lloyd, C.M., Snelgrove, R.J. Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection (2015) Nature Communications, 6 DOI: 10.1038/ncomms9423
• Castanhinha, S., Sherburn, R., Walker, S., Gupta, A., Bossley, C.J., Buckley, J., Ullmann, N., Grychtol, R., Campbell, G., Maglione, M., Koo, S., Fleming, L., Gregory, L., Snelgrove, R.J., Bush, A., Lloyd, C.M., Saglani, S. Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33(2015) Journal of Allergy and Clinical Immunology, 136 (2), pp. 312-322. DOI: 10.1016/j.jaci.2015.01.016
• Lloyd, C., Cullinan, P. Year in review 2014: Basic science and epidemiology (2015) Thorax, 70 (6), pp. 581-584. DOI: 10.1136/thoraxjnl-2015-207222
• Lloyd, C.M., Saglani, S. Epithelial cytokines and pulmonary allergic inflammation(2015) Current Opinion in Immunology, 34, pp. 52-58. DOI: 10.1016/j.coi.2015.02.001

• Lee, D.C.P., Walker, S.A., Byrne, A.J., Gregory, L.G., Buckley, J., Bush, A., Shaheen, S.O., Saglani, S., Lloyd, C.M. Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life(2015) Thorax, 70 (6), pp. 528-536. DOI: 10.1136/thoraxjnl-2014-205280
• Lloyd, C. Special delivery: How macrophages get the message across (2015) Journal of Experimental Medicine, 212 (5), p. 598. DOI: 10.1084/jem.2125insight1 

• Johnson, J.R., Folestad, E., Rowley, J.E., Noll, E.M., Walker, S.A., Lloyd, C.M., Rankin, S.M., Pietras, K., Eriksson, U., Fuxe, J. Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma(2015) American Journal of Physiology – Lung Cellular and Molecular Physiology, 308 (7), pp. L658-L671. DOI: 10.1152/ajplung.00286.2014
• Denney, L., Byrne, A.J., Shea, T.J., Buckley, J.S., Pease, J.E., Herledan, G.M.F., Walker, S.A., Gregory, L.G., Lloyd, C.M. Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function(2015) Immunity, 43 (5), pp. 945-958. DOI: 10.1016/j.immuni.2015.10.012
• Mathie, S.A., Dixon, K.L., Walker, S.A., Tyrrell, V., Mondhe, M., O’Donnell, V.B., Gregory, L.G., Lloyd, C.M. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge (2015) Allergy: European Journal of Allergy and Clinical Immunology, 70 (1), pp. 80-89. DOI: 10.1111/all.12536

2014

• Saglani, S., Lloyd, C.M. Eosinophils in the pathogenesis of paediatric severe asthma (2014) Current Opinion in Allergy and Clinical Immunology, 14 (2), pp. 143-148. DOI: 10.1097/ACI.0000000000000045
• Lloyd, C.M. Chair’s summary: Innate and adaptive immune responses in airway disease (2014) Annals of the American Thoracic Society, 11, pp. S234-S235. DOI: 10.1513/AnnalsATS.201405-210AW
• Cullinan, P., Lloyd, C.M. Year in review 2013: Basic science and epidemiology (2014) Thorax, 69 (6), pp. 505-507. DOI: 10.1136/thoraxjnl-2014-205423
• Murdoch, J.R., Gregory, L.G., Lloyd, C.M. γδT cells regulate chronic airway inflammation and development of airway remodelling (2014) Clinical and Experimental Allergy, 44 (11), pp. 1386-1398. DOI: 10.1111/cea.12395

• Snelgrove, R.J., Gregory, L.G., Peiró, T., Akthar, S., Campbell, G.A., Walker, S.A., Lloyd, C.M. Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations (2014) Journal of Allergy and Clinical Immunology, 134 (3), pp. 583-592. DOI: 10.1016/j.jaci.2014.02.002
• Vasiliou, J.E., Lui, S., Walker, S.A., Chohan, V., Xystrakis, E., Bush, A., Hawrylowicz, C.M., Saglani, S., Lloyd, C.M. Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease (2014) Allergy: European Journal of Allergy and Clinical Immunology, 69 (10), pp. 1380-1389. DOI: 10.1111/all.12465
• Gollwitzer, E.S., Saglani, S., Trompette, A., Yadava, K., Sherburn, R., McCoy, K.D., Nicod, L.P., Lloyd, C.M., Marsland, B.J. Lung microbiota promotes tolerance to allergens in neonates via PD-L1(2014) Nature Medicine, 20 (6), pp. 642-647. DOI: 10.1038/nm.3568 
• Moldaver, D.M., Bharhani, M.S., Wattie, J.N., Ellis, R., Neighbour, H., Lloyd, C.M., Inman, M.D., Larché, M. Amelioration of ovalbumin-induced allergic airway disease following der p 1 peptide immunotherapy is not associated with induction of IL-35(2014) Mucosal Immunology, 7 (2), pp. 379-390. DOI: 10.1038/mi.2013.56
• Campbell, J.D., Kell, S.A., Kozy, H.M., Lum, J.A., Sweetwood, R., Chu, M., Cunningham, C.R., Salamon, H., Lloyd, C.M., Coffman, R.L., Hessel, E.M. A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice (2014) Thorax, 69 (6), pp. 565-573. DOI: 10.1136/thoraxjnl-2013-204605

2013

• Gregory, L.G., Jones, C.P., Mathie, S.A., Pegorier, S., Lloyd, C.M.Endothelin-1 directs airway remodeling and hyper-reactivity in a murine asthma model (2013) Allergy: European Journal of Allergy and Clinical Immunology, 68 (12), pp. 1579-1588. DOI: 10.1111/all.12271
• Lloyd, C., Lewkowich, I.P., Wills-Karp, M., Saglani, S. Mouse Models of Allergic Airways Disease (2013) Middleton’s Allergy: Principles and Practice: Eighth Edition, 1-2, pp. 842-860. DOI: 10.1016/B978-0-323-08593-9.00052-8
• Saglani, S., Lui, S., Ullmann, N., Campbell, G.A., Sherburn, R.T., Mathie, S.A., Denney, L., Bossley, C.J., Oates, T., Walker, S.A., Bush, A., Lloyd, C.M. IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma(2013) Journal of Allergy and Clinical Immunology, 132 (3), pp. 676-685. DOI: 10.1016/j.jaci.2013.04.012
• Lloyd, C.M., Saglani, S. Eosinophils in the Spotlight: Finding the link between obesity and asthma (2013) Nature Medicine, 19 (8), pp. 976-977. DOI: 10.1038/nm.3296
• Byrne, A.J., Jones, C.P., Gowers, K., Rankin, S.M., Lloyd, C.M. Lung Macrophages Contribute to House Dust Mite Driven Airway Remodeling via HIF-1α (2013) PLoS ONE, 8 (7) DOI: 10.1371/journal.pone.0069246
• Cullinan, P., Lloyd, C. The double macchiato years; awards for the best basic science and epidemiology papers in 2012(2013) Thorax, 68 (8), pp. 777-779. DOI: 10.1136/thoraxjnl-2013-203961
• Lloyd, C.M., Saglani, S. T cells in asthma: Influences of genetics, environment, and T-cell plasticity (2013) Journal of Allergy and Clinical Immunology, 131 (5), pp. 1267-1274. DOI: 10.1016/j.jaci.2013.02.016
• Zhao, J., Lloyd, C.M., Noble, A. Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodelling (2013) Mucosal Immunology, 6 (2), pp. 335-346. DOI: 10.1038/mi.2012.76
• Gregory, L.G., Jones, C.P., Walker, S.A., Sawant, D., Gowers, K.H.C., Campbell, G.A., McKenzie, A.N.J., Lloyd, C.M. IL-25 drives remodelling in allergic airways disease induced by house dust mite(2013) Thorax, 68 (1), pp. 82-90. DOI: 10.1136/thoraxjnl-2012-202003
• Krauss-Etschmann, S., Bush, A., Bellusci, S., Brusselle, G.G., Dahlén, S.E.K., Dehmel, S., Eickelberg, O., Gibson, G., Hylkema, M.N., Knaus, P., Königshoff, M., Lloyd, C.M., MacCiarini, P., Mailleux, A., Marsland, B.J., Postma, D.S., Roberts, G., Samakovlis, C., Stocks, J., Vandesompele, J., Wjst, M., Holloway, J. Of flies, mice and men: A systematic approach to understanding the early life origins of chronic lung disease (2013) Thorax, 68 (4), pp. 380-384. DOI: 10.1136/thoraxjnl-2012-201902

2012

• Hammond, V.J., Morgan, A.H., Lauder, S., Thomas, C.P., Brown, S., Freeman, B.A., Lloyd, C.M., Davies, J., Bush, A., Levonen, A.-L., Kansanen, E., Villacorta, L., Chen, Y.E., Porter, N., Garcia-Diaz, Y.M., Schopfer, F.J., O’Donnell, V.B. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ(2012) Journal of Biological Chemistry, 287 (50), pp. 41651-41666. DOI: 10.1074/jbc.M112.405407
• Habibzay, M., Saldana, J.I., Goulding, J., Lloyd, C.M., Hussell, T. Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung (2012) Mucosal Immunology, 5 (5), pp. 524-534. DOI: 10.1038/mi.2012.28
• Jones, C.P., Gregory, L.G., Causton, B., Campbell, G.A., Lloyd, C.M. Activin A and TGF-β promote T H9 cell-mediated pulmonary allergic pathology (2012) Journal of Allergy and Clinical Immunology, 129 (4), pp. 1000-1010. DOI: 10.1016/j.jaci.2011.12.965
• Bossley, C.J., Fleming, L., Gupta, A., Regamey, N., Frith, J., Oates, T., Tsartsali, L., Lloyd, C.M., Bush, A., Saglani, S. Pediatric severe asthma is characterized by eosinophilia and remodeling without T H2 cytokines (2012) Journal of Allergy and Clinical Immunology, 129 (4), pp. 974-982.e13. DOI: 10.1016/j.jaci.2012.01.059
• Tan, H.-L., Davies, J., Brown, S., Lloyd, C.M., Bush, A., Regamey, N. Interleukin-17 and cystic fibrosis lung disease (2012) American Journal of Respiratory and Critical Care Medicine, 185 (1), pp. 109-110. DOI: 10.1164/ajrccm.185.1.109

2011

• Gregory, L.G., Lloyd, C.M. Orchestrating house dust mite-associated allergy in the lung (2011) Trends in Immunology, 32 (9), pp. 402-411. DOI: 10.1016/j.it.2011.06.006
• Tan, H.-L., Regamey, N., Brown, S., Bush, A., Lloyd, C.M., Davies, J.C. The Th17 pathway in cystic fibrosis lung disease (2011) American Journal of Respiratory and Critical Care Medicine, 184 (2), pp. 252-258. DOI: 10.1164/rccm.201102-0236OC
• Kearley, J., Erjefalt, J.S., Andersson, C., Benjamin, E., Jones, C.P., Robichaud, A., Pegorier, S., Brewah, Y., Burwell, T.J., Bjermer, L., Kiener, P.A., Kolbeck, R., Lloyd, C.M., Coyle, A.J., Humbles, A.A. IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways(2011) American Journal of Respiratory and Critical Care Medicine, 183 (7), pp. 865-875. DOI: 10.1164/rccm.200909-1462OC

2010

• Lloyd, C.M.IL-33 family members and asthma – bridging innate and adaptive immune responses (2010) Current Opinion in Immunology, 22 (6), pp. 800-806. DOI: 10.1016/j.coi.2010.10.006
• Lloyd, C.M., Hessel, E.M. Functions of T cells in asthma: More than just TH2 cells (2010) Nature Reviews Immunology, 10 (12), pp. 838-848. DOI: 10.1038/nri2870
• Chu, H.W., Lloyd, C.M., Karmaus, W., Maestrelli, P., Mason, P., Salcedo, G., Thaikoottathil, J., Wardlaw, A.J. Developments in the field of allergy in 2009 through the eyes of Clinical and Experimental Allergy(2010) Clinical and Experimental Allergy, 40 (11), pp. 1611-1631. DOI: 10.1111/j.1365-2222.2010.03625.x
• Otero, K., Vecchi, A., Hirsch, E., Kearley, J., Vermi, W., Del Prete, A., Gonzalvo-Feo, S., Garlanda, C., Azzolino, O., Salogni, L., Lloyd, C.M., Facchetti, F., Mantovani, A., Sozzani, S.  Nonredundant role of CCRL2 in lung dendritic cell trafficking(2010) Blood, 116 (16), pp. 2942-2949. DOI: 10.1182/blood-2009-12-259903
• Banfield, G., Watanabe, H., Scadding, G., Jacobson, M.R., Till, S.J., Hall, D.A., Robinson, D.S., Lloyd, C.M., Nouri-Aria, K.T., Durham, S.R. CC Chemokine Receptor 4 (CCR4) in human allergen-induced late nasal responses (2010) Allergy: European Journal of Allergy and Clinical Immunology, 65 (9), pp. 1126-1133. DOI: 10.1111/j.1398-9995.2010.02327.x
• Murdoch, J.R., Lloyd, C.M. Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing γδT cells(2010) American Journal of Respiratory and Critical Care Medicine, 182 (4), pp. 464-476. DOI: 10.1164/rccm.200911-1775OC
• Murdoch, J.R., Lloyd, C.M. Chronic inflammation and asthma (2010) Mutation Research – Fundamental and Molecular Mechanisms of Mutagenesis, 690 (1-2), pp. 24-39. DOI: 10.1016/j.mrfmmm.2009.09.005
• Gregory, L.G., Mathie, S.A., Walker, S.A., Pegorier, S., Jones, C.P., Lloyd, C.M. Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25(2010) American Journal of Respiratory and Critical Care Medicine, 182 (2), pp. 143-154. DOI: 10.1164/rccm.200905-0725OC
• Lloyd, C.M., Murdoch, J.R. Tolerizing allergic responses in the lung (2010) Mucosal Immunology, 3 (4), pp. 334-344. DOI: 10.1038/mi.2010.19
• Pegorier, S., Campbell, G.A., Kay, A.B., Lloyd, C.M. Bone Morphogenetic Protein (BMP)-4 and BMP-7 regulate differentially Transforming Growth Factor (TGF)-β1 in normal human lung fibroblasts (NHLF) (2010) Respiratory Research, 11 DOI: 10.1186/1465-9921-11-85
• Lloyd, C.M., Saglani, S. Asthma and allergy: The emerging epithelium (2010) Nature Medicine, 16 (3), pp. 273-274. DOI: 10.1038/nm0310-273

2009

• Jones, C.P., Pitchford, S.C., Lloyd, C.M., Rankin, S.M.CXCR2 mediates the recruitment of endothelial progenitor cells during allergic airways remodelling (2009) Stem Cells, 27 (12), pp. 3074-3081. DOI: 10.1002/stem.222
• Gregory, L.G., Causton, B., Murdoch, J.R., Mathie, S.A., O’Donnell, V., Thomas, C.P., Priest, F.M., Quint, D.J., Lloyd, C.M. Inhaled house dust mite induces pulmonary T helper 2 cytokine production(2009) Clinical and Experimental Allergy, 39 (10), pp. 1597-1610. DOI: 10.1111/j.1365-2222.2009.03302.x
• Lloyd, C.M., Hawrylowicz, C.M. Regulatory T Cells in Asthma (2009) Immunity, 31 (3), pp. 438-449. DOI: 10.1016/j.immuni.2009.08.007
• Saglani, S., Mathie, S.A., Gregory, L.G., Bell, M.J., Bush, A., Lloyd, C.M. Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice(2009) American Journal of Respiratory Cell and Molecular Biology, 41 (3), pp. 281-289. DOI: 10.1165/rcmb.2008-0396OC
• Kariyawasam, H.H., Pegorier, S., Barkans, J., Xanthou, G., Aizen, M., Ying, S., Kay, A.B., Lloyd, C.M., Robinson, D.S. Activin and transforming growth factor-β signaling pathways are activated after allergen challenge in mild asthma(2009) Journal of Allergy and Clinical Immunology, 124 (3), pp. 454-462. DOI: 10.1016/j.jaci.2009.06.022
• Morgan, A.H., Dioszeghy, V., Maskrey, B.H., Thomas, C.P., Clark, S.R., Mathie, S.A., Lloyd, C.M., Kühn, H., Topley, N., Coles, B.C., Taylor, P.R., Jones, S.A., O’Donnell, V.B. Phosphatidylethanolamine-esterified eicosanoids in the mouse. Tissue localization and inflammation-dependent formation in Th-2 disease (2009) Journal of Biological Chemistry, 284 (32), pp. 21185-21191. DOI: 10.1074/jbc.M109.021634
• Semitekolou, M., Alissafi, T., Aggelakopoulou, M., Kourepini, E., Kariyawasam, H.H., Kay, A.B., Robinson, D.S., Lloyd, C.M., Panoutsakopoulou, V., Xanthou, G. Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease (2009) Journal of Experimental Medicine, 206 (8), pp. 1769-1785. DOI: 10.1084/jem.20082603
• Ahern, D., Lloyd, C.M., Robinson, D.S. Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25- T cells from atopic and nonatopic donors(2009) Allergy: European Journal of Allergy and Clinical Immunology, 64 (8), pp. 1121-1129. DOI: 10.1111/j.1398-9995.2008.01962.x
• Campbell, J.D., Buckland, K.F., McMillan, S.J., Kearley, J., Oldfield, W.L.G., Stern, L.J., Grönlund, H., Van Hage, M., Reynolds, C.J., Boyton, R.J., Cobbold, S.P., Kay, A.B., Altmann, D.M., Lloyd, C.M., Larché, M. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression (2009) Journal of Experimental Medicine, 206 (7), pp. 1535-1547. DOI: 10.1084/jem.20082901
• Kearley, J., Buckland, K.F., Mathie, S.A., Lloyd, C.M. Resolution of allergic inflammation and airway hyperreactivity is dependentupon disruption of the T1/ST2-IL-33 pathway(2009) American Journal of Respiratory and Critical Care Medicine, 179 (9), pp. 772-781. DOI: 10.1164/rccm.200805-666OC
• Lloyd, C.M. Dust mites’ dirty dealings in the lung (2009) Nature Medicine, 15 (4), pp. 366-367. DOI: 10.1038/nm0409-366
• Lloyd, C.M. Airway Remodeling in Small Animal Models(2009) Allergy and Allergic Diseases, Second Edition, 1, pp. 1202-1213. DOI: 10.1002/9781444300918.ch55
• Wells, J.W., Choy, K., Lloyd, C.M., Noble, A. Suppression of allergic airway inflammation and IgE responses by a class I restricted allergen peptide vaccine (2009) Mucosal Immunology, 2 (1), pp. 54-62. DOI: 10.1038/mi.2008.69

2008

• Leggat, J.A., Gibbons, D.L., Haque, S.F.Y., Smith, A.L., Wells, J.W., Choy, K., Lloyd, C.M., Hayday, A.C., Noble, A. Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization (2008) Journal of Allergy and Clinical Immunology, 122 (5), pp. 1014-1021. DOI: 10.1016/j.jaci.2008.08.011
• Kearley, J., Robinson, D.S., Lloyd, C.M. CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling(2008) Journal of Allergy and Clinical Immunology, 122 (3), pp. 617-624.e6. DOI: 10.1016/j.jaci.2008.05.048
• Francis, J.N., Sabroe, I., Lloyd, C.M., Durham, S.R., Till, S.J. Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response(2008) Clinical and Experimental Immunology, 152 (3), pp. 440-447. DOI: 10.1111/j.1365-2249.2008.03657.x

• Tourdot, S., Mathie, S., Hussell, T., Edwards, L., Wang, H., Openshaw, P.J.M., Schwarze, J., Lloyd, C.M. Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization(2008) Clinical and Experimental Allergy, 38 (6), pp. 1016-1024. DOI: 10.1111/j.1365-2222.2008.02974.x
• Bartlett, N.W., Walton, R.P., Edwards, M.R., Aniscenko, J., Caramori, G., Zhu, J., Glanville, N., Choy, K.J., Jourdan, P., Burnet, J., Tuthill, T.J., Pedrick, M.S., Hurle, M.J., Plumpton, C., Sharp, N.A., Bussell, J.N., Swallow, D.M., Schwarze, J., Guy, B., Almond, J.W., Jeffery, P.K., Lloyd, C.M., Papi, A., Killington, R.A., Rowlands, D.J., Blair, E.D., Clarke, N.J., Johnston, S.L. Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation(2008) Nature Medicine, 14 (2), pp. 199-204. DOI: 10.1038/nm1713

2007

• Kearley, J., McMillan, S.J., Lloyd, C.M. Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo (2007) Journal of Experimental Medicine, 204 (6), pp. 1289-1294. DOI: 10.1084/jem.20062093
• Lloyd, C.M., Robinson, D.S. Allergen-induced airway remodelling (2007) European Respiratory Journal, 29 (5), pp. 1020-1032. DOI: 10.1183/09031936.00150305
• Trivedi, S.G., Lloyd, C.M. Eosinophils in the pathogenesis of allergic airways disease (2007) Cellular and Molecular Life Sciences, 64 (10), pp. 1269-1289. DOI: 10.1007/s00018-007-6527-y
• Xanthou, G., Alissafi, T., Semitekolou, M., Simoes, D.C.M., Economidou, E., Gaga, M., Lambrecht, B.N., Lloyd, C.M., Panoutsakopoulou, V. Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets (2007) Nature Medicine, 13 (5), pp. 570-578. DOI: 10.1038/nm1580
• Lloyd, C.M. Building better mouse models of asthma (2007) Current Allergy and Asthma Reports, 7 (3), pp. 231-236. DOI: 10.1007/s11882-007-0077-0
• Francis, J.N., Lloyd, C.M., Sabroe, I., Durham, S.R., Till, S.J. T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy (2007) Allergy: European Journal of Allergy and Clinical Immunology, 62 (1), pp. 59-65. DOI: 10.1111/j.1398-9995.2006.01253.x

2006

• Schüttelkopf, A.W., Andersen, O.A., Rao, F.V., Allwood, M., Lloyd, C., Eggleston, I.M., Van Aalten, D.M.F. Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor(2006) Journal of Biological Chemistry, 281 (37), pp. 27278-27285. DOI: 10.1074/jbc.M604048200
• Lloyd, C.M., Brown, Z. Chemokine receptors: Therapeutic potential in asthma (2006) Treatments in Respiratory Medicine, 5 (3), pp. 159-166. DOI: 10.2165/00151829-200605030-00002
• Uller, L., Lloyd, C.M., Rydell-Törmänen, K., Persson, C.G.A., Erjefält, J.S. Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation (2006) Clinical and Experimental Allergy, 36 (1), pp. 111-121. DOI: 10.1111/j.1365-2222.2006.02396.x

2005

• Kearley, J., Barker, J.E., Robinson, D.S., Lloyd, C.M. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent(2005) Journal of Experimental Medicine, 202 (11), pp. 1539-1547. DOI: 10.1084/jem.20051166
• McMillan, S.J., Xanthou, G., Lloyd, C.M. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-β antibody: Effect on the Smad signaling pathway (2005) Journal of Immunology, 174 (9), pp. 5774-5780.
• McMillan, S.J., Xanthou, G., Lloyd, C.M. Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling (2005) Clinical and Experimental Allergy, 35 (3), pp. 388-396. DOI: 10.1111/j.1365-2222.02193.x
• Behmer, S.T., Lloyd, C.M., Raubenheimer, D., Stewart-Clark, J., Knight, J., Leighton, R.S., Harper, F.A., Smith, J.A.C. Metal hyperaccumulation in plants: Mechanisms of defence against insect herbivores (2005) Functional Ecology, 19 (1), pp. 55-66. DOI: 10.1111/j.0269-8463.2005.00943.x

2004

• Humbles, A.A., Lloyd, C.M., McMillan, S.J., Friend, D.S., Xanthou, G., McKenna, E.E., Ghiran, S., Gerard, N.P., Yu, C., Orkin, S.H., Gerard, C. A critical role for eosinophils in allergic airways remodelling (2004) Science, 305 (5691), pp. 1776-1779. DOI: 10.1126/science.1100283
• Lloyd, C.M., Gutierrez-Ramos, J.C. Animal models to study chemokine receptor function: in vivo mouse models of allergic airway inflammation. (2004) Methods in molecular biology (Clifton, N.J.), 239, pp. 199-210.
• McMillan, S.J., Lloyd, C.M. Prolonged allergen challenge in mice leads to persistent airway remodelling (2004) Clinical and Experimental Allergy, 34 (3), pp. 497-507. DOI: 10.1111/j.1365-2222.2004.01895.x
• McMillan, S.J., Kearley, J., Campbell, J.D., Zhu, X.-W., Larbi, K.Y., Shipley, J.M., Senior, R.M., Nourshargh, S., Lloyd, C.M. Matrix Metalloproteinase-9 Deficiency Results in Enhanced Allergen-Induced Airway Inflammation(2004) Journal of Immunology, 172 (4), pp. 2586-2594. DOI: 10.4049/jimmunol.172.4.2586
• Lloyd, C.M., Robinson, D.S., McMillan, S.J. Modelling airway remodelling in asthma (2004) Drug Discovery Today: Disease Models, 1 (4), pp. 425-430. DOI: 10.1016/j.ddmod.2004.11.013
• Francis, J.N., Jacobson, M.R., Lloyd, C.M., Sabroe, I., Durham, S.R., Till, S.J.CXCR1+CD4+ T Cells in Human Allergic Disease(2004) Journal of  Immunology, 172 (1), pp. 268-273. DOI: 10.4049/jimmunol.172.1.268

2003

• Conroy, D.M., Jopling, L.A., Lloyd, C.M., Hodge, M.R., Andrew, D.P., Williams, T.J., Pease, J.E., Sabroe, I. CCR4 blockade does not inhibit allergic airways inflammation(2003) Journal of Leukocyte Biology, 74 (4), pp. 558-563. DOI: 10.1189/jlb.0103030
• Lloyd, C.M., Rankin, S.M. Chemokines in allergic airway disease (2003) Current Opinion in Pharmacology, 3 (4), pp. 443-448. DOI: 10.1016/S1471-4892(03)00069-9
• Bishop, B., Lloyd, C.M.CC chemokine ligand 1 promotes recruitment of eosinophils but not Th2 cells during the development of allergic airways disease (2003) Journal of Immunology, 170 (9), pp. 4810-4817. DOI: 10.4049/jimmunol.170.9.4810
• Banwell, M.E., Robinson, D.S., Lloyd, C.M. Adenoid-derived TH2 cells reactive to allergen and recall antigen express CC chemokine receptor 4 (2003) Journal of Allergy and Clinical Immunology, 112 (6), pp. 1155-1161. DOI: 10.1016/j.jaci.2003.08.029

2002

• Nouri-Aria, K.T., Wilson, D., Francis, J.N., Jopling, L.A., Jacobson, M.R., Hodge, M.R., Andrew, D.P., Till, S.J., Varga, E.-M., Williams, T.J., Pease, J.E., Lloyd, C.M., Sabroe, I., Durham, S.R.CCR4 in human allergen-induced late responses in the skin and lung(2002) European Journal of Immunology, 32 (7), pp. 1933-1938. DOI: 10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-R
• Robinson, D.S., Lloyd, C.M. Asthma: T-bet – A master controller? (2002) Current Biology, 12 (9), pp. R322-R324. DOI: 10.1016/S0960-9822(02)00830-8
• Sabroe, I., Lloyd, C.M., Whyte, M.K.B., Dower, S.K., Williams, T.J., Pease, J.E. Chemokines, innate and adaptive immunity, and respiratory disease (2002) European Respiratory Journal, 19 (2), pp. 350-355. DOI: 10.1183/09031936.02.00253602
• Lloyd, C. Chemokines in allergic lung inflammation (2002) Immunology, 105 (2), pp. 144-154. DOI: 10.1046/j.1365-2567.2002.01344.x
• McMillan, S.J., Bishop, B., Townsend, M.J., McKenzie, A.N., Lloyd, C.M.The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity (2002) Journal of Experimental Medicine, 195 (1), pp. 51-57. DOI: 10.1084/jem.20011732

2001

• Lloyd, C.M., Gonzalo, J.-A., Nguyen, T., Delaney, T., Tian, J., Oettgen, H., Coyle, A.J., Gutierrez-Ramos, J.-C. Resolution of bronchial hyperresponsiveness and pulmonary inflammation is associated with IL-3 and tissue leukocyte apoptosis (2001) Journal of Immunology, 166 (3), pp. 2033-2040. DOI: 10.4049/jimmunol.166.3.2033
• Lloyd, C.M., Gonzalo, J.-A., Coyle, A.J., Gutierrez-Ramos, J.-C. Mouse models of allergic airway disease (2001) Advances in Immunology, 77, pp. 263-295. DOI: 10.1016/S0065-2776(01)77019-8

2000

• Coyle, A.J., Lloyd, C.M., Gutierrez-Ramos, J.-C. Biotherapeutic targets for the treatment of allergic airway disease (2000) American Journal of Respiratory and Critical Care Medicine, 162 (4 II), pp. S179-S184.
• Lloyd, C., Gutierrez-Ramos, J.C. Murine model of crescentic nephritis. (2000) Methods in molecular biology (Clifton, N.J.), 138, pp. 311-318.
• Gonzalo, J.-A., Lloyd, C.M., Peled, A., Delaney, T., Coyle, A.J., Gutierrez-Ramos, J.-C. Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1α in the inflammatory component of allergic airway disease (2000) Journal of Immunology, 165 (1), pp. 499-508.
• Lloyd, C.M., Delaney, T., Nguyen, T., Tian, J., Martinez-A, C., Coyle, A.J., Gutierrez-Ramos, J.-C.CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte- derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo (2000) Journal of Experimental Medicine, 191 (2), pp. 265-273. DOI: 10.1084/jem.191.2.265
• Gutierrez-Ramos, J.-C., Lloyd, C., Kapsenberg, M.L., Gonzalo, J.A., Coyle, A.J. Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung (2000) Immunological Reviews, 177, pp. 31-42. DOI: 10.1034/j.1600-065X.2000.17713.x
• Coyle, A.J., Lehar, S., Lloyd, C., Tian, J., Delaney, T., Manning, S., Nguyen, T., Burwell, T., Schneider, H., Gonzalo, J.A., Gosselin, M., Owen, L.R., Rudd, C.E., Gutierrez-Ramos, J.C. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses (2000) Immunity, 13 (1), pp. 95-105. DOI: 10.1016/S1074-7613(00)00011-X

1999

• Gutierrez-Ramos, J.C., Lloyd, C., Gonzalo, J.A. Eotaxin: From an eosinophilic chemokine to a major regulator of allergic reactions (1999) Immunology Today, 20 (11), pp. 500-504. DOI: 10.1016/S0167-5699(99)01522-4
• Coyle, A.J., Lloyd, C., Tian, J., Nguyen, T., Erikkson, C., Wang, L., Ottoson, P., Persson, P., Delaney, T., Lehar, S., Lin, S., Poisson, L., Meisel, C., Kamradt, T., Bjerke, T., Levinson, D., Gutierrez-Ramos, J.C. Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses (1999) Journal of Experimental Medicine, 190 (7), pp. 895-902. DOI: 10.1084/jem.190.7.895
• Lou, Y., Lloyd, C., Gutierrez-Ramos, J.-C., Dorf, M.E. Chemokine amplification in mesangial cells (1999) Journal of Immunology, 163 (7), pp. 3985-3992.
• Gonzalo, J.-A., Pan, Y., Lloyd, C.M., Jia, G.-Q., Yu, G., Dussault, B., Powers, C.A., Proudfoot, A.E.I., Coyle, A.J., Gearing, D., Gutierrez-Ramos, J.-C. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation (1999) Journal of Immunology, 163 (1), pp. 403-411.
• Gerwin, N., Gonzalo, J.-A., Lloyd, C., Coyle, A.J., Reiss, Y., Banu, N., Wang, B., Hong, X., Avraham, H., Engelhardt, B., Springer, T.A., Gutierrez-Ramos, J.C. Prolonged eosinophil accumulation in allergic lung interstitium of ICAM- 2-deficient mice results in extended hyperresponsiveness (1999) Immunity, 10 (1), pp. 9-19. DOI: 10.1016/S1074-7613(00)80002-3

1998

• Gonzalo, J.-A., Lloyd, C.M., Wen, D., Albar, J.P., Wells, T.N.C., Proudfoot, A., Martinez-A, C., Dorf, M., Bjerke, T., Coyle, A.J., Gutierrez-Ramos, J.-C. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness (1998) Journal of Experimental Medicine, 188 (1), pp. 157-167. DOI: 10.1084/jem.188.1.157
• Lloyd, C., Gutierrez-Ramos, J.-C.The role of chemokines in tissue inflammation and autoimmunity in renal diseases (1998) Current Opinion in Nephrology and Hypertension, 7 (3), pp. 281-287.
• Peled, A., Gonzalo, J.A., Lloyd, C., Gutierrez-Ramos, J.-C. The chemotactic cytokine Eotaxin acts as a granulocyte-macrophage colony-stimulating factor during lung inflammation (1998) Blood, 91 (6), pp. 1909-1916.

1997

• Lloyd, C.M., Dorf, M.E., Proudfoot, A., Salant, D.J., Gutierrez-Ramos, J.-C. Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritis (1997) Journal of Leukocyte Biology, 62 (5), pp. 676-680.
• Lloyd, C.M., Gonzalo, J.-A., Salant, D.J., Just, J., Gutierrez-Ramos, J.-C. Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus (1997) Journal of Clinical Investigation, 100 (5), pp. 963-971. DOI: 10.1172/JCI119647
• Pan, Y., Lloyd, C., Zhou, H., Dolich, S., Deeds, J., Gonzalo, J.-A., Vath, J., Gosselin, M., Ma, J., Dussault, B., Woolf, E., Alperin, G., Culpepper, J., Gutierrez-Ramos, J.C., Gearing, D. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation (1997) Nature, 387 (6633), pp. 611-617. DOI: 10.1038/42491
• Lloyd, C.M., Minto, A.W., Dorf, M.E., Proudfoot, A., Wells, T.N.C., Salant, D.J., Gutierrez-Ramos, J.-C. RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis(1997) Journal of Experimental Medicine, 185 (7), pp. 1371-1380. DOI: 10.1084/jem.185.7.1371

1996

• Gonzalo, J.-A., Lloyd, C.M., Kremer, L., Finger, E., Martinez-A., C., Siegelman, M.H., Cybulsky, M., Gutierrez-Ramos, J.-C. Eosinophil recruitment to the lung in a murine model of allergic inflammation: The role of T cells, chemokines, and adhesion receptors (1996) Journal of Clinical Investigation, 98 (10), pp. 2332-2345. DOI: 10.1172/JCI119045
• Jia, G.-Q., Gonzalo, J.A., Lloyd, C., Kremer, L., Lu, L., Martinez-A, C., Wershil, B.K., Gutierrez-Ramos, J.C. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation(1996) Journal of Experimental Medicine, 184 (5), pp. 1939-1951. DOI: 10.1084/jem.184.5.1939

1995

• Andrews, P.A., Finn, J.E., Lloyd, C.M., Zhou, W., Mathieson, P.W., Sacks, S.H. Expression and tissue localization of donor‐specific complement C3 synthesized in human renal allografts(1995) European Journal of Immunology, 25 (4), pp. 1087-1093. DOI: 10.1002/eji.1830250434

1994

• Andrews, P.A., Lloyd, C.M., Webb, M.C., Sacks, S.H. Acute interstitial nephritis associated with mycoplasma pneumoniae infection (1994) Nephrology Dialysis Transplantation, 9 (5), pp. 564-566. DOI: 10.1093/ndt/9.5.564
• Lloyd, C.M., Collins, I., Belcher, A.J., Manuelpillai, N., Wozencraft, A.O., Staines, N.A. Characterization and pathological significance of monoclonal DNA-binding antibodies from mice with experimental malaria infection (1994) Infection and Immunity, 62 (5), pp. 1982-1988.

1993

• Lloyd, C.M., Wozencraft, A.O., Williams, D.G. Cell-mediated pathology during murine malaria-associated nephritis (1993) Clinical and Experimental Immunology, 94 (3), pp. 398-402.

1990

• Wozencraft, A.O., Lloyd, C.M., Staines, M.A., Griffiths, V.J. Role of DNA-binding antibodies in kidney pathology associated with murine malaria infections (1990) Infection and Immunity, 58 (7), pp. 2156-2164.