Régis Joulia – BHF Junior Research Fellow
I am BHF Junior Research Fellow from the Imperial BHF Centre of Excellence. I joined Imperial College in July 2021 after 4 years of post-doctoral research at the William Harvey Research Institute, QMUL, in the group of Prof. Sussan Nourshargh. Prior to this, I was awarded a PhD in immunology from the University of Toulouse Paul Sabatier III under the supervision of Dr. Eric Espinosa and Dr. Salvatore Valitutti in 2016.
My research is mainly focus on the early steps of inflammation response and specifically on a particular immune cell type called mast cells. These cells are critical to initiate the inflammation process and are responsible for most of allergy disorders. During my PhD, I used cutting edge imaging approaches to decipher the mechanisms of mast cell degranulation.
While in Prof Sussan Noursargh’s laboratory, I developed new mouse models to analyse inflammation responses using confocal intra-vital imaging approaches. I then moved to Imperial College to study mast cell and pericyte interaction in the context of lung inflammation.
- Pyle CJ, Patel DF, Peiró T, Joulia R, Grabiec AM, Hussell T, Tavernier G, Simpson A, Pease J, Harker JA, Lloyd CM, Snelgrove RJ. MMP-12 Supports Pulmonary B Cell Follicle Formation and Local Antibody Responses During Asthma. Am J Respir Crit Care Med. 2022 Aug 9. https://doi.org/10.1164/rccm.202109-2082LE
- Leveque E, Joulia R, Petitfils C, Mas-Orea X, Payros G, Laurent C et al. T helper cell-licensed mast cells promote inflammatory Th17 cells. bioRxiv 2021: https://doi.org/2021.2007.2028.454103
- Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T, Nourshargh S. Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Immunity. 2021 Jul 13;54(7):1494-1510.e7. https://doi.org/10.1016/j.immuni.2021.04.025
- Owen-Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum AF, Arkill KP, Stein M, Girbl T, Golding M, Bates DO, Vestweber D, Voisin MB, Nourshargh S. Local microvascular leakage promotes trafficking of activated neutrophils to remote organs. J Clin Invest. 2020 May 1;130(5):2301-2318. https://doi.org/10.1172/JCI133661
- Valitutti, S., Joulia, R., Espinosa, E. (2017). The Mast Cell Antibody-Dependent Degranulatory Synapse. In: Baldari, C., Dustin, M. (eds) The Immune Synapse. Methods in Molecular Biology, vol 1584. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6881-7_30
- Joulia R, Mailhol C, Valitutti S, Didier A, Espinosa E. Direct monitoring of basophil degranulation by using avidin-based probes. J Allergy Clin Immunol. 2017 Oct;140(4):1159-1162.e6. https://doi.org/10.1016/j.jaci.2017.03.030
- Joulia R, L’Faqihi FE, Valitutti S, Espinosa E. IL-33 fine tunes mast cell degranulation and chemokine production at the single-cell level. J Allergy Clin Immunol. 2017 Aug;140(2):497-509.e10. https://doi.org/10.1016/j.jaci.2016.09.049
- Joulia, R., Gaudenzio, N., Rodrigues, M. et al. Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence. Nat Commun 6, 6174 (2015). https://doi.org/10.1038/ncomms7174
- Nicolas Gaudenzio, Regis Joulia, Salvatore Valitutti, Eric Espinosa. Vectorial Exposure and Fusion Of Secretory Granule Content At The Mast Cell Degranulatory Synapse. Journal of Allergy and Clinical Immunology, 2014. https://doi.org/10.1016/j.jaci.2013.12.236