{"id":109,"date":"2018-07-05T19:10:03","date_gmt":"2018-07-05T18:10:03","guid":{"rendered":"http:\/\/lloydlab.co.uk\/?page_id=109"},"modified":"2026-05-12T13:45:40","modified_gmt":"2026-05-12T12:45:40","slug":"yuki-ishii","status":"publish","type":"page","link":"https:\/\/lloydlab.co.uk\/index.php\/people\/yuki-ishii\/","title":{"rendered":"Yuki Ishii"},"content":{"rendered":"\t\t
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\u00a0<\/p>

\"\"Yuki Ishii – Research Manager<\/h4>

As Research Manager, I support the research led by Professor Clare Lloyd, which focuses on the mechanisms of inflammation, tissue repair, and remodelling in chronic lung disease. <\/s><\/span>I contribute to the coordination and delivery of research projects within the group, support the development of new experimental approaches, and assist with grant applications and manuscript preparation. I work closely with research staff and play an active role in supervising and mentoring undergraduate and postgraduate students, as well as supporting teaching and training within the lab. I also help facilitate collaborations and organise lab activities.<\/span><\/p>

I obtained my PhD in Japan, where I studied regulators of growth and differentiation in leukemia. I then moved to New York for postdoctoral training at\u00a0<\/span>Icahn School of Medicine at Mount Sinai, focusing on the development of novel combination therapies for breast cancer. <\/span>Following this, I relocated to San Diego and worked as a Project Scientist at UC San Diego, investigating mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemic. I later joined the Ludwig Institute for Cancer Research as a Research Associate, where I worked on developing compounds targeting synthetic lethal vulnerabilities in breast and ovarian cancers. <\/span>After moving to London, I joined UCL\u2019s Respiratory Department as a Senior Research Fellow, contributing to projects on mesothelioma, lung regeneration, and lung cancer before joining the Lloyd Lab in 2026.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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y.ishii@imperial.ac.uk<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Publications (selected)<\/strong><\/h3>
  • Ishii.Y<\/strong>, Orr.JC, El Mdawar.M, Bairros de Pilger.DR, Pearce.DR, Lazarus.KA, et al<\/em>. Compound screening in primary human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies. J. Cell Science<\/em> (2025)<\/li>
  • Ishii.Y<\/strong>, Kolluri.KK, Pennycuick.A, Zhang.X, Nigro.E, Alrifai.D, et al<\/em>. BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma. J.Biol.Chem<\/em> (2021)<\/li>
  • Guo.E#<\/sup>, Ishii.Y<\/strong>#<\/sup>, Mueller.J, Srivatsan.A, Gahman.T, Putnam.CD, Wang.JY, Kolodner.RD. FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination. PNAS<\/em> (2020)<\/li>
  • Kolluri.KK#<\/sup>, Alifrangis.C#<\/sup>, Kumar.N#<\/sup>, Ishii.Y<\/strong>#<\/sup>, Price.S, Michaut.M, et al<\/em>. Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. Elife<\/em> (2018)<\/li>
  • Ishii.Y<\/strong>, Nhiayi. MK, Tse. E, Cheng. J, Massimino. M, Durden. DL, et al<\/em>. Knockout serum replacement promotes cell survival by preventing BIM from inducing mitochondrial cytochrome c<\/em> release. PLOS ONE<\/em> (2015)<\/li>
  • Ishii.Y<\/strong>, Papa. L, Bahadur U, Yue Z, Aguirre-Ghiso J, Shioda T, et al<\/em>.\u00a0\u00a0 Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein response. Clin. Cancer Res<\/em> (2011)<\/li>
  • Ishii.Y<\/strong>, Waxman.S, Germain.D. Tamoxifen stimulates the growth of cyclin D1 overexpressing breast cancer cells by promoting the activation of STAT3. Cancer Res<\/em> (2008)<\/li>
  • Ishii.Y<\/strong>, Pirkmaier.A, Alvarez.JV, Frank.DA, Kaselman.I, et al<\/em>. Cyclin D1 overexpression and response to Bortezomib treatment in a breast cancer model. JNCI<\/em> (2006).<\/li>
  • Ishii.Y<\/strong>, Kasukabe.T, Honma.Y.\u00a0 Induction of CCAAT\/enhancer binding protein-delta by cytokinins, but not by retinoic acid, during granulocytic differentiation of human myeloid leukemia cells. Bri. J. Haematol<\/em> (2005)<\/li>
  • Ishii.Y<\/strong>, Hori.Y, Sakai.S, Honma.Y.\u00a0 Control of differentiation and apoptosis human myeloid leukemia cells by cytokinin and cytokinin nucleosides, plant redifferentiation-inducing hormones. Cell Growth Differ<\/em> (2002)<\/li><\/ul>

    \u00a0#<\/sup><\/em>These authors contributed equally.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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    Yuki Ishii – Research Manager As Research Manager, I support the research led by Professor Clare Lloyd, which focuses on the mechanisms of inflammation, tissue repair, and remodelling in chronic lung disease. I contribute to the coordination and delivery of research projects within the group, support the development of new experimental approaches, and assist with […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":79,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","footnotes":""},"class_list":["post-109","page","type-page","status-publish","hentry","entry","owp-thumbs-layout-horizontal","owp-btn-normal","owp-tabs-layout-horizontal","has-no-thumbnails","has-product-nav"],"_links":{"self":[{"href":"https:\/\/lloydlab.co.uk\/index.php\/wp-json\/wp\/v2\/pages\/109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lloydlab.co.uk\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lloydlab.co.uk\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lloydlab.co.uk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lloydlab.co.uk\/index.php\/wp-json\/wp\/v2\/comments?post=109"}],"version-history":[{"count":51,"href":"https:\/\/lloydlab.co.uk\/index.php\/wp-json\/wp\/v2\/pages\/109\/revisions"}],"predecessor-version":[{"id":4166,"href":"https:\/\/lloydlab.co.uk\/index.php\/wp-json\/wp\/v2\/pages\/109\/revisions\/4166"}],"up":[{"embeddable":true,"href":"https:\/\/lloydlab.co.uk\/index.php\/wp-json\/wp\/v2\/pages\/79"}],"wp:attachment":[{"href":"https:\/\/lloydlab.co.uk\/index.php\/wp-json\/wp\/v2\/media?parent=109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}