Imperial College London

Here is a list of publications by year:

2019

Branchett WJ, Stölting H, Oliver RA, Walker SA, Puttur F, Gregory LG, Gabryšová L, Wilson MS, O’Garra A, Lloyd CM. A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma. J Allergy Clin Immunol. 2019 Aug 22. pii: S0091-6749(19)31079-6. doi:10.1016/j.jaci.2019.08.006.

Lloyd CM, Saglani S. Opening the Window of Immune Opportunity: Treating Childhood Asthma. Trends Immunol. 2019 Sep;40(9):786-798. doi: 10.1016/j.it.2019.07.004.

Invernizzi R, Molyneaux PL. The contribution of infection and the respiratory microbiome in acute exacerbations of idiopathic pulmonary fibrosis. Eur Respir Rev 2019; 28: 190045. doi: 10/1183/16000617.0045-2019

Singhania A, Graham CM, Gabrysova L, Moreira-Teixeira L, Stavropoulos E, Pitt JM, Chakravarty P, Warnatsch A, Branchett WJ, Conejero L, Lin JW, Davidson S, Wilson MS, Bancroft G, Langhorne J, Frickel E, Sesay AK, Priestnall SL, Herbert E, Ioannou M, Wang Q, Humphreys IR, Dodd J, Openshaw PJM, Mayer-Barber KD, Jankovic D, Sher A, Lloyd CM, Baldwin N, Chaussabel D, Papayannopoulos V, Wack A, Banchereau JF, Pascual VM, O’Garra A. Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nat Commun. 2019 Jun 28;10(1): 2887. doi: 10.1038/s4167-019-10601-6. 

Turnbull AR, Pyle CJ, Patel DF, Jackson PL, Hilliard TN, Regamey N, Tan HL, Brown S, Thursfield R, Short C, Mc Fie M, Alton EWFW, Gaggar A, Blalock JE, Lloyd CM, Bush A, Davies JC, Snelgrove RJ. Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis .J Cyst Fibros. 2019 Jun 5. pii: S1569-1993(19)30769-6. doi: 10.1016/j.jcf.2019.05.017.

Puttur F, Denney L, Gregory LG, Vuononvirta J, Oliver R, Entwistle LJ, Walker SA, Headley MB, McGhee EJ, Pease JE, Krummel MF, Carlin LM, Lloyd CM. Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans. Sci Immunol. 2019 Jun 7;4(36). pii: eaav7638. doi: 10.1126/sciimmunol.aav7638.

Nagakumar P, Puttur F, Gregory LG, Denney L, Fleming L, Bush A, Lloyd CM, Saglani S. Pulmonary type2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids. Eur Respir J. 2019 Jun 4. pii: 1801809. doi: 10.1183/13993003.01809-2018. 

Allden SJ, Ogger PP, Ghai P, McErlean P, Hewitt R, Toshner R, Walker SA, Saunders P, Kingston S, Molyneaux PL, Maher TM, Lloyd CM, Byrne AJ. The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. doi: 10.1164/rccm.201809-1775OC.

Branchett WJ, Lloyd CM. Regulatory cytokine function in the respiratory tract. Mucosal Immunol. 2019 May;12(3):589-600. doi: 10.1038/s41385-019-0158-0.

Puttur F, Gregory LG, Lloyd CM. Airway macrophages as the guardians of tissue  repair in the lung. Immunol Cell Biol. 2019 Mar;97(3):246-257. doi: 10.1111/imcb.12235.

Davies ER, Denney L, Wandel M, Lloyd CM, Davies DE, Haitchi HM. Regulation of ectodomain shedding of ADAM33 in vitro and in vivo. J Allergy Clin Immunol. doi: 10.1016/j.jaci.2019.01.026.

2018

Robinson PFM, Pattaroni C, Cook J, Gregory L, Alonso AM, Fleming LJ, Lloyd CM, Bush A, Marsland BJ, Saglani S.  Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze. (2018) J Allergy Clin Immunol. doi: 10.1016/j.jaci.2018.12.985.

Zhang Y, Willis-Owen SAG, Spiegel S, Lloyd CM, Moffatt MF, Cookson WOCM. The ORMDL3 Asthma Gene Regulates ICAM1 and has Multiple Effects on Cellular Inflammation. (2018) Am J Respir Crit Care Med . doi: 10.1164/rccm.201803-0438OC.

Uwadiae FI, Pyle CJ, Walker SA, Lloyd CM, Harker JA. Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease. (2018) Allergy.  doi: 10.1111/all.13602.

Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ,
Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA,
Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM. Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13(+)CD4(+) T cells. (2018) Science Immunol., 7;3(27). doi: 10.1126/sciimmunol.aan4128.

Turner S, Custovic A, Ghazal P, Grigg J, Gore M, Henderson J, Lloyd CM,
Marsland B, Power UF, Roberts G, Saglani S, Schwarze J, Shields M, Bush A.
Pulmonary epithelial barrier and immunological functions at birth and in early life – key determinants of the development of asthma?  A description of the protocol for the Breathing Together study. Wellcome Open Res. (2018) doi: 10.12688/wellcomeopenres.14489.1.

Snelgrove, R.J., Patel, D.F., Patel, T., Lloyd, C.M. The enigmatic role of the neutrophil in asthma: Friend, foe or indifferent? (2018) Clinical and Experimental Allergy, 48 (10), pp. 1275-1285. DOI: 10.1111/cea.13191

Patel, D.F., Peiró, T., Shoemark, A., Akthar, S., Walker, S.A., Grabiec, A.M., Jackson, P.L., Hussell, T., Gaggar, A., Xu, X., Trevor, J.L., Li, J., Steele, C., Tavernier, G., Edwin Blalock, J., Niven, R.M., Gregory, L.G., Simpson, A., Lloyd, C.M., Snelgrove, R.J.An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness(2018) Science Translational Medicine, 10 (455) DOI: 10.1126/scitranslmed.aaq0693

Lloyd CM, Snelgrove RJ. Type 2 immunity: Expanding our view. (2018) Sci Immunol. doi: 10.1126/sciimmunol.aat1604.

Snelgrove, R.J., Lloyd, C.M. Tasting type 2 inflammation in the airways (2018) Journal of Allergy and Clinical Immunology, 142 (2), pp. 403-404. DOI: 10.1016/j.jaci.2018.06.009

Lloyd, C.M., Harker, J.A. Epigenetic control of interleukin-9 in asthma(2018) New England Journal of Medicine, 379 (1), pp. 87-89. DOI: 10.1056/NEJMcibr1803610 

Meiners, S., Lloyd, C., Chambers, R.C. Cell–matrix interactions in lung disease and regeneration: ERS lung science conference 2018 report (2018) European Respiratory Review, 27 (148) DOI: 10.1183/16000617.0040-2018

Peiró, T., Patel, D.F., Akthar, S., Gregory, L.G., Pyle, C.J., Harker, J.A., Birrell, M.A., Lloyd, C.M., Snelgrove, R.J. Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection (2018) Thorax, 73 (6), pp. 546-556. DOI: 10.1136/thoraxjnl-2017-210010

Saglani, S., Lloyd, C.M. The Immunopathogenesis of Asthma (2018) Kendig’s Disorders of the Respiratory Tract in Children, pp. 665-676 DOI: 10.1016/B978-0-323-44887-1.00043-2

Saglani, S., Lloyd, C.M., Bush, A. Biology and Assessment of Airway Inflammation (2018) Kendig’s Disorders of the Respiratory Tract in Children, pp. 101-119 DOI: 10.1016/B978-0-323-44887-1.00007-9

Denney, L., Branchett, W., Gregory, L.G., Oliver, R.A., Lloyd, C.M.Epithelial-derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection (2018) Mucosal Immunology, 11 (2), pp. 523-535. DOI: 10.1038/mi.2017.77

Pavord, I.D., Beasley, R., Agusti, A., Anderson, G.P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F.M., Fahy, J.V., Frey, U., Gibson, P., Heaney, L.G., Holt, P.G., Humbert, M., Lloyd, C.M., Marks, G., Martinez, F.D., Sly, P.D., von Mutius, E., Wenzel, S., Zar, H.J., Bush, A. After asthma: redefining airways diseases (2018) The Lancet, 391 (10118), pp. 350-400. DOI: 10.1016/S0140-6736(17)30879-6

Zhang, Y., Poobalasingam, T., Yates, L.L., Walker, S.A., Taylor, M.S., Chessum, L., Harrison, J., Tsaprouni, L., Adcock, I.M., Lloyd, C.M., Cookson, W.O., Moffatt, M.F., Dean, C.H.Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma (2018) DMM Disease Models and Mechanisms, 11 (1) DOI: 10.1242/dmm.031369

2017

Dean, C.H., Lloyd, C.M.Lung Alveolar Repair: Not All Cells Are Equal (2017) Trends in Molecular Medicine, 23 (10), pp. 871-873. DOI: 10.1016/j.molmed.2017.08.009

Snelgrove, R.J., Lloyd, C.M. An NLRP3, IL-1β, neutrophil axis in the respiratory tract leaves you breathless(2017) American Journal of Respiratory and Critical Care Medicine, 196 (3), pp. 253-254. DOI: 10.1164/rccm.201703-0483ED

Lloyd, C.M., Saglani, S. Development of allergic immunity in early life (2017) Immunological Reviews, 278 (1), pp. 101-115. DOI: 10.1111/imr.12562

Weiss, G., Lai, C., Fife, M.E., Grabiec, A.M., Tildy, B., Snelgrove, R.J., Xin, G., Lloyd, C.M., Hussell, T. Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors(2017) Mucosal Immunology, 10 (4), pp. 1021-1030. DOI: 10.1038/mi.2016.104

Andersson, C.K., Adams, A., Nagakumar, P., Bossley, C., Gupta, A., De Vries, D., Adnan, A., Bush, A., Saglani, S., Lloyd, C.M. Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function(2017) Journal of Allergy and Clinical Immunology, 139 (6), pp. 1819-1829 DOI: 10.1016/j.jaci.2016.09.022

Byrne, A.J., Weiss, M., Mathie, S.A., Walker, S.A., Eames, H.L., Saliba, D., Lloyd, C.M., Udalova, I.A. A critical role for IRF5 in regulating allergic airway inflammation(2017) Mucosal Immunology, 10 (3), pp. 716-726. DOI: 10.1038/mi.2016.92

Löser, S., Gregory, L.G., Zhang, Y., Schaefer, K., Walker, S.A., Buckley, J., Denney, L., Dean, C.H., Cookson, W.O.C., Moffatt, M.F., Lloyd, C.M. Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease (2017) Journal of Allergy and Clinical Immunology, 139 (5), pp. 1496-1507 DOI: 10.1016/j.jaci.2016.07.033

Edwards, M.R., Saglani, S., Schwarze, J., Skevaki, C., Smith, J.A., Ainsworth, B., Almond, M., Andreakos, E., Belvisi, M.G., Chung, K.F., Cookson, W., Cullinan, P., Hawrylowicz, C., Lommatzsch, M., Jackson, D., Lutter, R., Marsland, B., Moffatt, M., Thomas, M., Virchow, J.C., Xanthou, G., Edwards, J., Walker, S., Johnston, S.L., Adcock, I., Akdis, C., Bel, E., Bousquet, J., Ten Brinke, A., Brusselle, G., Dáhlen, S.-E., Djukanovic, R., Gaga, M., Garcia-Marcos, L., Hiemstra, P., Heffler, E., Holgate, S., Kupczyk, M., Lloyd, C., Lucas, J., Magnan, A., Martin, T., Myles, D., Page, C., Palkonen, S., Papadopoulos, N., Papi, A., Powell, P., Riley, J., Sayers, I., Spanevello, A., Sterk, P., Xepapadaki, P., Wheelock, .C. Addressing unmet needs in understanding asthma mechanisms (2017) European Respiratory Journal, 49 (5) DOI: 10.1183/13993003.02448-2016

Lloyd, C.M., Marsland, B.J. Lung Homeostasis: Influence of Age, Microbes, and the Immune System (2017) Immunity, 46 (4), pp. 549-561. DOI: 10.1016/j.immuni.2017.04.005

Poobalasingam, T., Yates, L.L., Walker, S.A., Pereira, M., Gross, N.Y., Ali, A., Kolatsi-Joannou, M., Jarvelin, M.-R., Pekkanen, J., Papakrivopoulou, E., Long, D.A., Griffiths, M., Wagner, D., Konigshoff, M., Hind, M., Minelli, C., Lloyd, C.M., Dean, C.H. Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair(2017) DMM Disease Models and Mechanisms, 10 (4), pp. 409-423. DOI: 10.1242/dmm.028175

Low, C.M., Akthar, S., Patel, D.F., Löser, S., Wong, C.-T., Jackson, P.L., Blalock, J.E., Hare, S.A., Lloyd, C.M., Snelgrove, R.J. The development of novel LTA4 H modulators to selectively target LTB4 generation (2017) Scientific Reports, 7 DOI: 10.1038/srep44449

2016

Byrne, A.J., Maher, T.M., Lloyd, C.M. Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease? (2016) Trends in Molecular Medicine, 22 (4), pp. 303-316. DOI: 10.1016/j.molmed.2016.02.004

Nagakumar, P., Denney, L., Fleming, L., Bush, A., Lloyd, C.M., Saglani, S. Type 2 innate lymphoid cells in induced sputum from children with severe asthma (2016) Journal of Allergy and Clinical Immunology, 137 (2), pp. 624-626. DOI: 10.1016/j.jaci.2015.06.038

Lloyd, C.M., Harker, J.A. Location, Location, Location: Localized Memory Cells Take Residence in the Allergic Lung (2016) Immunity, 44 (1), pp. 13-15. DOI: 10.1016/j.immuni.2015.12.012

Saglani, S., Lloyd, C.M. Prostacyclin as a potential novel means to manipulate type 2 innate lymphoid cell function(2016) American Journal of Respiratory and Critical Care Medicine, 193 (1), pp. 2-4. DOI: 10.1164/rccm.201509-1773ED

2015

Saglani, S., Lloyd, C.M. Novel concepts in airway inflammation and remodelling in asthma (2015) European Respiratory Journal, 46 (6), pp. 1796-1804. DOI: 10.1183/13993003.01196-2014

Byrne, A.J., Mathie, S.A., Gregory, L.G., Lloyd, C.M. Pulmonary macrophages: Key players in the innate defence of the airways (2015) Thorax, 70 (12), pp. 1189-1196. DOI: 10.1136/thoraxjnl-2015-207020

Akthar, S., Patel, D.F., Beale, R.C., Peiró, T., Xu, X., Gaggar, A., Jackson, P.L., Blalock, J.E., Lloyd, C.M., Snelgrove, R.J. Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection (2015) Nature Communications, 6 DOI: 10.1038/ncomms9423

Castanhinha, S., Sherburn, R., Walker, S., Gupta, A., Bossley, C.J., Buckley, J., Ullmann, N., Grychtol, R., Campbell, G., Maglione, M., Koo, S., Fleming, L., Gregory, L., Snelgrove, R.J., Bush, A., Lloyd, C.M., Saglani, S. Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33(2015) Journal of Allergy and Clinical Immunology, 136 (2), pp. 312-322. DOI: 10.1016/j.jaci.2015.01.016

Lloyd, C., Cullinan, P. Year in review 2014: Basic science and epidemiology (2015) Thorax, 70 (6), pp. 581-584. DOI: 10.1136/thoraxjnl-2015-207222

Lloyd, C.M., Saglani, S. Epithelial cytokines and pulmonary allergic inflammation(2015) Current Opinion in Immunology, 34, pp. 52-58. DOI: 10.1016/j.coi.2015.02.001

Lee, D.C.P., Walker, S.A., Byrne, A.J., Gregory, L.G., Buckley, J., Bush, A., Shaheen, S.O., Saglani, S., Lloyd, C.M. Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life(2015) Thorax, 70 (6), pp. 528-536. DOI: 10.1136/thoraxjnl-2014-205280

Lloyd, C. Special delivery: How macrophages get the message across (2015) Journal of Experimental Medicine, 212 (5), p. 598. DOI: 10.1084/jem.2125insight1 

Johnson, J.R., Folestad, E., Rowley, J.E., Noll, E.M., Walker, S.A., Lloyd, C.M., Rankin, S.M., Pietras, K., Eriksson, U., Fuxe, J. Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma(2015) American Journal of Physiology – Lung Cellular and Molecular Physiology, 308 (7), pp. L658-L671. DOI: 10.1152/ajplung.00286.2014

Denney, L., Byrne, A.J., Shea, T.J., Buckley, J.S., Pease, J.E., Herledan, G.M.F., Walker, S.A., Gregory, L.G., Lloyd, C.M. Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function(2015) Immunity, 43 (5), pp. 945-958. DOI: 10.1016/j.immuni.2015.10.012

Mathie, S.A., Dixon, K.L., Walker, S.A., Tyrrell, V., Mondhe, M., O’Donnell, V.B., Gregory, L.G., Lloyd, C.M. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge (2015) Allergy: European Journal of Allergy and Clinical Immunology, 70 (1), pp. 80-89. DOI: 10.1111/all.12536

2014

Saglani, S., Lloyd, C.M. Eosinophils in the pathogenesis of paediatric severe asthma (2014) Current Opinion in Allergy and Clinical Immunology, 14 (2), pp. 143-148. DOI: 10.1097/ACI.0000000000000045

Lloyd, C.M. Chair’s summary: Innate and adaptive immune responses in airway disease (2014) Annals of the American Thoracic Society, 11, pp. S234-S235. DOI: 10.1513/AnnalsATS.201405-210AW

Cullinan, P., Lloyd, C.M. Year in review 2013: Basic science and epidemiology (2014) Thorax, 69 (6), pp. 505-507. DOI: 10.1136/thoraxjnl-2014-205423

Murdoch, J.R., Gregory, L.G., Lloyd, C.M. γδT cells regulate chronic airway inflammation and development of airway remodelling (2014) Clinical and Experimental Allergy, 44 (11), pp. 1386-1398. DOI: 10.1111/cea.12395

Snelgrove, R.J., Gregory, L.G., Peiró, T., Akthar, S., Campbell, G.A., Walker, S.A., Lloyd, C.M. Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations (2014) Journal of Allergy and Clinical Immunology, 134 (3), pp. 583-592. DOI: 10.1016/j.jaci.2014.02.002

Vasiliou, J.E., Lui, S., Walker, S.A., Chohan, V., Xystrakis, E., Bush, A., Hawrylowicz, C.M., Saglani, S., Lloyd, C.M. Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease (2014) Allergy: European Journal of Allergy and Clinical Immunology, 69 (10), pp. 1380-1389. DOI: 10.1111/all.12465

Gollwitzer, E.S., Saglani, S., Trompette, A., Yadava, K., Sherburn, R., McCoy, K.D., Nicod, L.P., Lloyd, C.M., Marsland, B.J. Lung microbiota promotes tolerance to allergens in neonates via PD-L1(2014) Nature Medicine, 20 (6), pp. 642-647. DOI: 10.1038/nm.3568 

Moldaver, D.M., Bharhani, M.S., Wattie, J.N., Ellis, R., Neighbour, H., Lloyd, C.M., Inman, M.D., Larché, M. Amelioration of ovalbumin-induced allergic airway disease following der p 1 peptide immunotherapy is not associated with induction of IL-35(2014) Mucosal Immunology, 7 (2), pp. 379-390. DOI: 10.1038/mi.2013.56

Campbell, J.D., Kell, S.A., Kozy, H.M., Lum, J.A., Sweetwood, R., Chu, M., Cunningham, C.R., Salamon, H., Lloyd, C.M., Coffman, R.L., Hessel, E.M. A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice (2014) Thorax, 69 (6), pp. 565-573. DOI: 10.1136/thoraxjnl-2013-204605

2013

Gregory, L.G., Jones, C.P., Mathie, S.A., Pegorier, S., Lloyd, C.M.Endothelin-1 directs airway remodeling and hyper-reactivity in a murine asthma model (2013) Allergy: European Journal of Allergy and Clinical Immunology, 68 (12), pp. 1579-1588. DOI: 10.1111/all.12271

Lloyd, C., Lewkowich, I.P., Wills-Karp, M., Saglani, S. Mouse Models of Allergic Airways Disease (2013) Middleton’s Allergy: Principles and Practice: Eighth Edition, 1-2, pp. 842-860. DOI: 10.1016/B978-0-323-08593-9.00052-8

Saglani, S., Lui, S., Ullmann, N., Campbell, G.A., Sherburn, R.T., Mathie, S.A., Denney, L., Bossley, C.J., Oates, T., Walker, S.A., Bush, A., Lloyd, C.M. IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma(2013) Journal of Allergy and Clinical Immunology, 132 (3), pp. 676-685. DOI: 10.1016/j.jaci.2013.04.012

Lloyd, C.M., Saglani, S. Eosinophils in the Spotlight: Finding the link between obesity and asthma (2013) Nature Medicine, 19 (8), pp. 976-977. DOI: 10.1038/nm.3296

Byrne, A.J., Jones, C.P., Gowers, K., Rankin, S.M., Lloyd, C.M. Lung Macrophages Contribute to House Dust Mite Driven Airway Remodeling via HIF-1α (2013) PLoS ONE, 8 (7) DOI: 10.1371/journal.pone.0069246

Cullinan, P., Lloyd, C. The double macchiato years; awards for the best basic science and epidemiology papers in 2012(2013) Thorax, 68 (8), pp. 777-779. DOI: 10.1136/thoraxjnl-2013-203961

Lloyd, C.M., Saglani, S. T cells in asthma: Influences of genetics, environment, and T-cell plasticity (2013) Journal of Allergy and Clinical Immunology, 131 (5), pp. 1267-1274. DOI: 10.1016/j.jaci.2013.02.016

Zhao, J., Lloyd, C.M., Noble, A. Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodelling (2013) Mucosal Immunology, 6 (2), pp. 335-346. DOI: 10.1038/mi.2012.76

Gregory, L.G., Jones, C.P., Walker, S.A., Sawant, D., Gowers, K.H.C., Campbell, G.A., McKenzie, A.N.J., Lloyd, C.M. IL-25 drives remodelling in allergic airways disease induced by house dust mite(2013) Thorax, 68 (1), pp. 82-90. DOI: 10.1136/thoraxjnl-2012-202003

Krauss-Etschmann, S., Bush, A., Bellusci, S., Brusselle, G.G., Dahlén, S.E.K., Dehmel, S., Eickelberg, O., Gibson, G., Hylkema, M.N., Knaus, P., Königshoff, M., Lloyd, C.M., MacCiarini, P., Mailleux, A., Marsland, B.J., Postma, D.S., Roberts, G., Samakovlis, C., Stocks, J., Vandesompele, J., Wjst, M., Holloway, J. Of flies, mice and men: A systematic approach to understanding the early life origins of chronic lung disease (2013) Thorax, 68 (4), pp. 380-384. DOI: 10.1136/thoraxjnl-2012-201902

2012

Hammond, V.J., Morgan, A.H., Lauder, S., Thomas, C.P., Brown, S., Freeman, B.A., Lloyd, C.M., Davies, J., Bush, A., Levonen, A.-L., Kansanen, E., Villacorta, L., Chen, Y.E., Porter, N., Garcia-Diaz, Y.M., Schopfer, F.J., O’Donnell, V.B. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ(2012) Journal of Biological Chemistry, 287 (50), pp. 41651-41666. DOI: 10.1074/jbc.M112.405407

Habibzay, M., Saldana, J.I., Goulding, J., Lloyd, C.M., Hussell, T. Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung (2012) Mucosal Immunology, 5 (5), pp. 524-534. DOI: 10.1038/mi.2012.28

Jones, C.P., Gregory, L.G., Causton, B., Campbell, G.A., Lloyd, C.M. Activin A and TGF-β promote T H9 cell-mediated pulmonary allergic pathology (2012) Journal of Allergy and Clinical Immunology, 129 (4), pp. 1000-1010. DOI: 10.1016/j.jaci.2011.12.965

Bossley, C.J., Fleming, L., Gupta, A., Regamey, N., Frith, J., Oates, T., Tsartsali, L., Lloyd, C.M., Bush, A., Saglani, S. Pediatric severe asthma is characterized by eosinophilia and remodeling without T H2 cytokines (2012) Journal of Allergy and Clinical Immunology, 129 (4), pp. 974-982.e13. DOI: 10.1016/j.jaci.2012.01.059

Tan, H.-L., Davies, J., Brown, S., Lloyd, C.M., Bush, A., Regamey, N. Interleukin-17 and cystic fibrosis lung disease (2012) American Journal of Respiratory and Critical Care Medicine, 185 (1), pp. 109-110. DOI: 10.1164/ajrccm.185.1.109

2011

Gregory, L.G., Lloyd, C.M. Orchestrating house dust mite-associated allergy in the lung (2011) Trends in Immunology, 32 (9), pp. 402-411. DOI: 10.1016/j.it.2011.06.006

Tan, H.-L., Regamey, N., Brown, S., Bush, A., Lloyd, C.M., Davies, J.C. The Th17 pathway in cystic fibrosis lung disease (2011) American Journal of Respiratory and Critical Care Medicine, 184 (2), pp. 252-258. DOI: 10.1164/rccm.201102-0236OC

Kearley, J., Erjefalt, J.S., Andersson, C., Benjamin, E., Jones, C.P., Robichaud, A., Pegorier, S., Brewah, Y., Burwell, T.J., Bjermer, L., Kiener, P.A., Kolbeck, R., Lloyd, C.M., Coyle, A.J., Humbles, A.A. IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways(2011) American Journal of Respiratory and Critical Care Medicine, 183 (7), pp. 865-875. DOI: 10.1164/rccm.200909-1462OC

2010

Lloyd, C.M.IL-33 family members and asthma – bridging innate and adaptive immune responses (2010) Current Opinion in Immunology, 22 (6), pp. 800-806. DOI: 10.1016/j.coi.2010.10.006

Lloyd, C.M., Hessel, E.M. Functions of T cells in asthma: More than just TH2 cells (2010) Nature Reviews Immunology, 10 (12), pp. 838-848. DOI: 10.1038/nri2870

Chu, H.W., Lloyd, C.M., Karmaus, W., Maestrelli, P., Mason, P., Salcedo, G., Thaikoottathil, J., Wardlaw, A.J. Developments in the field of allergy in 2009 through the eyes of Clinical and Experimental Allergy(2010) Clinical and Experimental Allergy, 40 (11), pp. 1611-1631. DOI: 10.1111/j.1365-2222.2010.03625.x

Otero, K., Vecchi, A., Hirsch, E., Kearley, J., Vermi, W., Del Prete, A., Gonzalvo-Feo, S., Garlanda, C., Azzolino, O., Salogni, L., Lloyd, C.M., Facchetti, F., Mantovani, A., Sozzani, S.  Nonredundant role of CCRL2 in lung dendritic cell trafficking(2010) Blood, 116 (16), pp. 2942-2949. DOI: 10.1182/blood-2009-12-259903

Banfield, G., Watanabe, H., Scadding, G., Jacobson, M.R., Till, S.J., Hall, D.A., Robinson, D.S., Lloyd, C.M., Nouri-Aria, K.T., Durham, S.R. CC Chemokine Receptor 4 (CCR4) in human allergen-induced late nasal responses (2010) Allergy: European Journal of Allergy and Clinical Immunology, 65 (9), pp. 1126-1133. DOI: 10.1111/j.1398-9995.2010.02327.x

Murdoch, J.R., Lloyd, C.M. Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing γδT cells(2010) American Journal of Respiratory and Critical Care Medicine, 182 (4), pp. 464-476. DOI: 10.1164/rccm.200911-1775OC

Murdoch, J.R., Lloyd, C.M. Chronic inflammation and asthma (2010) Mutation Research – Fundamental and Molecular Mechanisms of Mutagenesis, 690 (1-2), pp. 24-39. DOI: 10.1016/j.mrfmmm.2009.09.005

Gregory, L.G., Mathie, S.A., Walker, S.A., Pegorier, S., Jones, C.P., Lloyd, C.M. Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25(2010) American Journal of Respiratory and Critical Care Medicine, 182 (2), pp. 143-154. DOI: 10.1164/rccm.200905-0725OC

Lloyd, C.M., Murdoch, J.R. Tolerizing allergic responses in the lung (2010) Mucosal Immunology, 3 (4), pp. 334-344. DOI: 10.1038/mi.2010.19

Pegorier, S., Campbell, G.A., Kay, A.B., Lloyd, C.M. Bone Morphogenetic Protein (BMP)-4 and BMP-7 regulate differentially Transforming Growth Factor (TGF)-β1 in normal human lung fibroblasts (NHLF) (2010) Respiratory Research, 11 DOI: 10.1186/1465-9921-11-85

Lloyd, C.M., Saglani, S. Asthma and allergy: The emerging epithelium (2010) Nature Medicine, 16 (3), pp. 273-274. DOI: 10.1038/nm0310-273

2009

Jones, C.P., Pitchford, S.C., Lloyd, C.M., Rankin, S.M.CXCR2 mediates the recruitment of endothelial progenitor cells during allergic airways remodelling (2009) Stem Cells, 27 (12), pp. 3074-3081. DOI: 10.1002/stem.222

Gregory, L.G., Causton, B., Murdoch, J.R., Mathie, S.A., O’Donnell, V., Thomas, C.P., Priest, F.M., Quint, D.J., Lloyd, C.M. Inhaled house dust mite induces pulmonary T helper 2 cytokine production(2009) Clinical and Experimental Allergy, 39 (10), pp. 1597-1610. DOI: 10.1111/j.1365-2222.2009.03302.x

Lloyd, C.M., Hawrylowicz, C.M. Regulatory T Cells in Asthma (2009) Immunity, 31 (3), pp. 438-449. DOI: 10.1016/j.immuni.2009.08.007

Saglani, S., Mathie, S.A., Gregory, L.G., Bell, M.J., Bush, A., Lloyd, C.M. Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice(2009) American Journal of Respiratory Cell and Molecular Biology, 41 (3), pp. 281-289. DOI: 10.1165/rcmb.2008-0396OC

Kariyawasam, H.H., Pegorier, S., Barkans, J., Xanthou, G., Aizen, M., Ying, S., Kay, A.B., Lloyd, C.M., Robinson, D.S. Activin and transforming growth factor-β signaling pathways are activated after allergen challenge in mild asthma(2009) Journal of Allergy and Clinical Immunology, 124 (3), pp. 454-462. DOI: 10.1016/j.jaci.2009.06.022

Morgan, A.H., Dioszeghy, V., Maskrey, B.H., Thomas, C.P., Clark, S.R., Mathie, S.A., Lloyd, C.M., Kühn, H., Topley, N., Coles, B.C., Taylor, P.R., Jones, S.A., O’Donnell, V.B. Phosphatidylethanolamine-esterified eicosanoids in the mouse. Tissue localization and inflammation-dependent formation in Th-2 disease (2009) Journal of Biological Chemistry, 284 (32), pp. 21185-21191. DOI: 10.1074/jbc.M109.021634

Semitekolou, M., Alissafi, T., Aggelakopoulou, M., Kourepini, E., Kariyawasam, H.H., Kay, A.B., Robinson, D.S., Lloyd, C.M., Panoutsakopoulou, V., Xanthou, G. Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease (2009) Journal of Experimental Medicine, 206 (8), pp. 1769-1785. DOI: 10.1084/jem.20082603

Ahern, D., Lloyd, C.M., Robinson, D.S. Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25- T cells from atopic and nonatopic donors(2009) Allergy: European Journal of Allergy and Clinical Immunology, 64 (8), pp. 1121-1129. DOI: 10.1111/j.1398-9995.2008.01962.x

Campbell, J.D., Buckland, K.F., McMillan, S.J., Kearley, J., Oldfield, W.L.G., Stern, L.J., Grönlund, H., Van Hage, M., Reynolds, C.J., Boyton, R.J., Cobbold, S.P., Kay, A.B., Altmann, D.M., Lloyd, C.M., Larché, M. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression (2009) Journal of Experimental Medicine, 206 (7), pp. 1535-1547. DOI: 10.1084/jem.20082901

Kearley, J., Buckland, K.F., Mathie, S.A., Lloyd, C.M. Resolution of allergic inflammation and airway hyperreactivity is dependentupon disruption of the T1/ST2-IL-33 pathway(2009) American Journal of Respiratory and Critical Care Medicine, 179 (9), pp. 772-781. DOI: 10.1164/rccm.200805-666OC

Lloyd, C.M. Dust mites’ dirty dealings in the lung (2009) Nature Medicine, 15 (4), pp. 366-367. DOI: 10.1038/nm0409-366

Lloyd, C.M. Airway Remodeling in Small Animal Models(2009) Allergy and Allergic Diseases, Second Edition, 1, pp. 1202-1213. DOI: 10.1002/9781444300918.ch55

Wells, J.W., Choy, K., Lloyd, C.M., Noble, A. Suppression of allergic airway inflammation and IgE responses by a class I restricted allergen peptide vaccine (2009) Mucosal Immunology, 2 (1), pp. 54-62. DOI: 10.1038/mi.2008.69

2008

Leggat, J.A., Gibbons, D.L., Haque, S.F.Y., Smith, A.L., Wells, J.W., Choy, K., Lloyd, C.M., Hayday, A.C., Noble, A. Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization (2008) Journal of Allergy and Clinical Immunology, 122 (5), pp. 1014-1021. DOI: 10.1016/j.jaci.2008.08.011

Kearley, J., Robinson, D.S., Lloyd, C.M. CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling(2008) Journal of Allergy and Clinical Immunology, 122 (3), pp. 617-624.e6. DOI: 10.1016/j.jaci.2008.05.048

Francis, J.N., Sabroe, I., Lloyd, C.M., Durham, S.R., Till, S.J. Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response(2008) Clinical and Experimental Immunology, 152 (3), pp. 440-447. DOI: 10.1111/j.1365-2249.2008.03657.x

Tourdot, S., Mathie, S., Hussell, T., Edwards, L., Wang, H., Openshaw, P.J.M., Schwarze, J., Lloyd, C.M. Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization(2008) Clinical and Experimental Allergy, 38 (6), pp. 1016-1024. DOI: 10.1111/j.1365-2222.2008.02974.x

Bartlett, N.W., Walton, R.P., Edwards, M.R., Aniscenko, J., Caramori, G., Zhu, J., Glanville, N., Choy, K.J., Jourdan, P., Burnet, J., Tuthill, T.J., Pedrick, M.S., Hurle, M.J., Plumpton, C., Sharp, N.A., Bussell, J.N., Swallow, D.M., Schwarze, J., Guy, B., Almond, J.W., Jeffery, P.K., Lloyd, C.M., Papi, A., Killington, R.A., Rowlands, D.J., Blair, E.D., Clarke, N.J., Johnston, S.L. Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation(2008) Nature Medicine, 14 (2), pp. 199-204. DOI: 10.1038/nm1713

2007

Kearley, J., McMillan, S.J., Lloyd, C.M. Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo (2007) Journal of Experimental Medicine, 204 (6), pp. 1289-1294. DOI: 10.1084/jem.20062093

Lloyd, C.M., Robinson, D.S. Allergen-induced airway remodelling (2007) European Respiratory Journal, 29 (5), pp. 1020-1032. DOI: 10.1183/09031936.00150305

Trivedi, S.G., Lloyd, C.M. Eosinophils in the pathogenesis of allergic airways disease (2007) Cellular and Molecular Life Sciences, 64 (10), pp. 1269-1289. DOI: 10.1007/s00018-007-6527-y

Xanthou, G., Alissafi, T., Semitekolou, M., Simoes, D.C.M., Economidou, E., Gaga, M., Lambrecht, B.N., Lloyd, C.M., Panoutsakopoulou, V. Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets (2007) Nature Medicine, 13 (5), pp. 570-578. DOI: 10.1038/nm1580

Lloyd, C.M. Building better mouse models of asthma (2007) Current Allergy and Asthma Reports, 7 (3), pp. 231-236. DOI: 10.1007/s11882-007-0077-0

Francis, J.N., Lloyd, C.M., Sabroe, I., Durham, S.R., Till, S.J. T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy (2007) Allergy: European Journal of Allergy and Clinical Immunology, 62 (1), pp. 59-65. DOI: 10.1111/j.1398-9995.2006.01253.x

2006

Schüttelkopf, A.W., Andersen, O.A., Rao, F.V., Allwood, M., Lloyd, C., Eggleston, I.M., Van Aalten, D.M.F. Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor(2006) Journal of Biological Chemistry, 281 (37), pp. 27278-27285. DOI: 10.1074/jbc.M604048200

Lloyd, C.M., Brown, Z. Chemokine receptors: Therapeutic potential in asthma (2006) Treatments in Respiratory Medicine, 5 (3), pp. 159-166. DOI: 10.2165/00151829-200605030-00002

Uller, L., Lloyd, C.M., Rydell-Törmänen, K., Persson, C.G.A., Erjefält, J.S. Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation (2006) Clinical and Experimental Allergy, 36 (1), pp. 111-121. DOI: 10.1111/j.1365-2222.2006.02396.x

2005

Kearley, J., Barker, J.E., Robinson, D.S., Lloyd, C.M. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent(2005) Journal of Experimental Medicine, 202 (11), pp. 1539-1547. DOI: 10.1084/jem.20051166

McMillan, S.J., Xanthou, G., Lloyd, C.M. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-β antibody: Effect on the Smad signaling pathway (2005) Journal of Immunology, 174 (9), pp. 5774-5780.

McMillan, S.J., Xanthou, G., Lloyd, C.M. Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling (2005) Clinical and Experimental Allergy, 35 (3), pp. 388-396. DOI: 10.1111/j.1365-2222.02193.x

Behmer, S.T., Lloyd, C.M., Raubenheimer, D., Stewart-Clark, J., Knight, J., Leighton, R.S., Harper, F.A., Smith, J.A.C. Metal hyperaccumulation in plants: Mechanisms of defence against insect herbivores (2005) Functional Ecology, 19 (1), pp. 55-66. DOI: 10.1111/j.0269-8463.2005.00943.x

2004

Humbles, A.A., Lloyd, C.M., McMillan, S.J., Friend, D.S., Xanthou, G., McKenna, E.E., Ghiran, S., Gerard, N.P., Yu, C., Orkin, S.H., Gerard, C. A critical role for eosinophils in allergic airways remodelling (2004) Science, 305 (5691), pp. 1776-1779. DOI: 10.1126/science.1100283

Lloyd, C.M., Gutierrez-Ramos, J.C. Animal models to study chemokine receptor function: in vivo mouse models of allergic airway inflammation. (2004) Methods in molecular biology (Clifton, N.J.), 239, pp. 199-210.

McMillan, S.J., Lloyd, C.M. Prolonged allergen challenge in mice leads to persistent airway remodelling (2004) Clinical and Experimental Allergy, 34 (3), pp. 497-507. DOI: 10.1111/j.1365-2222.2004.01895.x

McMillan, S.J., Kearley, J., Campbell, J.D., Zhu, X.-W., Larbi, K.Y., Shipley, J.M., Senior, R.M., Nourshargh, S., Lloyd, C.M. Matrix Metalloproteinase-9 Deficiency Results in Enhanced Allergen-Induced Airway Inflammation(2004) Journal of Immunology, 172 (4), pp. 2586-2594. DOI: 10.4049/jimmunol.172.4.2586

Lloyd, C.M., Robinson, D.S., McMillan, S.J. Modelling airway remodelling in asthma (2004) Drug Discovery Today: Disease Models, 1 (4), pp. 425-430. DOI: 10.1016/j.ddmod.2004.11.013

Francis, J.N., Jacobson, M.R., Lloyd, C.M., Sabroe, I., Durham, S.R., Till, S.J.CXCR1+CD4+ T Cells in Human Allergic Disease(2004) Journal of  Immunology, 172 (1), pp. 268-273. DOI: 10.4049/jimmunol.172.1.268

2003

Conroy, D.M., Jopling, L.A., Lloyd, C.M., Hodge, M.R., Andrew, D.P., Williams, T.J., Pease, J.E., Sabroe, I. CCR4 blockade does not inhibit allergic airways inflammation(2003) Journal of Leukocyte Biology, 74 (4), pp. 558-563. DOI: 10.1189/jlb.0103030

Lloyd, C.M., Rankin, S.M. Chemokines in allergic airway disease (2003) Current Opinion in Pharmacology, 3 (4), pp. 443-448. DOI: 10.1016/S1471-4892(03)00069-9

Bishop, B., Lloyd, C.M.CC chemokine ligand 1 promotes recruitment of eosinophils but not Th2 cells during the development of allergic airways disease (2003) Journal of Immunology, 170 (9), pp. 4810-4817. DOI: 10.4049/jimmunol.170.9.4810

Banwell, M.E., Robinson, D.S., Lloyd, C.M. Adenoid-derived TH2 cells reactive to allergen and recall antigen express CC chemokine receptor 4 (2003) Journal of Allergy and Clinical Immunology, 112 (6), pp. 1155-1161. DOI: 10.1016/j.jaci.2003.08.029

2002

Nouri-Aria, K.T., Wilson, D., Francis, J.N., Jopling, L.A., Jacobson, M.R., Hodge, M.R., Andrew, D.P., Till, S.J., Varga, E.-M., Williams, T.J., Pease, J.E., Lloyd, C.M., Sabroe, I., Durham, S.R.CCR4 in human allergen-induced late responses in the skin and lung(2002) European Journal of Immunology, 32 (7), pp. 1933-1938. DOI: 10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-R

Robinson, D.S., Lloyd, C.M. Asthma: T-bet – A master controller? (2002) Current Biology, 12 (9), pp. R322-R324. DOI: 10.1016/S0960-9822(02)00830-8

Sabroe, I., Lloyd, C.M., Whyte, M.K.B., Dower, S.K., Williams, T.J., Pease, J.E. Chemokines, innate and adaptive immunity, and respiratory disease (2002) European Respiratory Journal, 19 (2), pp. 350-355. DOI: 10.1183/09031936.02.00253602

Lloyd, C. Chemokines in allergic lung inflammation (2002) Immunology, 105 (2), pp. 144-154. DOI: 10.1046/j.1365-2567.2002.01344.x

McMillan, S.J., Bishop, B., Townsend, M.J., McKenzie, A.N., Lloyd, C.M.The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity (2002) Journal of Experimental Medicine, 195 (1), pp. 51-57. DOI: 10.1084/jem.20011732

2001

Lloyd, C.M., Gonzalo, J.-A., Nguyen, T., Delaney, T., Tian, J., Oettgen, H., Coyle, A.J., Gutierrez-Ramos, J.-C. Resolution of bronchial hyperresponsiveness and pulmonary inflammation is associated with IL-3 and tissue leukocyte apoptosis (2001) Journal of Immunology, 166 (3), pp. 2033-2040. DOI: 10.4049/jimmunol.166.3.2033

Lloyd, C.M., Gonzalo, J.-A., Coyle, A.J., Gutierrez-Ramos, J.-C. Mouse models of allergic airway disease (2001) Advances in Immunology, 77, pp. 263-295. DOI: 10.1016/S0065-2776(01)77019-8

2000

Coyle, A.J., Lloyd, C.M., Gutierrez-Ramos, J.-C. Biotherapeutic targets for the treatment of allergic airway disease (2000) American Journal of Respiratory and Critical Care Medicine, 162 (4 II), pp. S179-S184.

Lloyd, C., Gutierrez-Ramos, J.C. Murine model of crescentic nephritis. (2000) Methods in molecular biology (Clifton, N.J.), 138, pp. 311-318.

Gonzalo, J.-A., Lloyd, C.M., Peled, A., Delaney, T., Coyle, A.J., Gutierrez-Ramos, J.-C. Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1α in the inflammatory component of allergic airway disease (2000) Journal of Immunology, 165 (1), pp. 499-508.

Lloyd, C.M., Delaney, T., Nguyen, T., Tian, J., Martinez-A, C., Coyle, A.J., Gutierrez-Ramos, J.-C.CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte- derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo (2000) Journal of Experimental Medicine, 191 (2), pp. 265-273. DOI: 10.1084/jem.191.2.265

Gutierrez-Ramos, J.-C., Lloyd, C., Kapsenberg, M.L., Gonzalo, J.A., Coyle, A.J. Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung (2000) Immunological Reviews, 177, pp. 31-42. DOI: 10.1034/j.1600-065X.2000.17713.x

Coyle, A.J., Lehar, S., Lloyd, C., Tian, J., Delaney, T., Manning, S., Nguyen, T., Burwell, T., Schneider, H., Gonzalo, J.A., Gosselin, M., Owen, L.R., Rudd, C.E., Gutierrez-Ramos, J.C. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses (2000) Immunity, 13 (1), pp. 95-105. DOI: 10.1016/S1074-7613(00)00011-X

1999

Gutierrez-Ramos, J.C., Lloyd, C., Gonzalo, J.A. Eotaxin: From an eosinophilic chemokine to a major regulator of allergic reactions (1999) Immunology Today, 20 (11), pp. 500-504. DOI: 10.1016/S0167-5699(99)01522-4

Coyle, A.J., Lloyd, C., Tian, J., Nguyen, T., Erikkson, C., Wang, L., Ottoson, P., Persson, P., Delaney, T., Lehar, S., Lin, S., Poisson, L., Meisel, C., Kamradt, T., Bjerke, T., Levinson, D., Gutierrez-Ramos, J.C. Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses (1999) Journal of Experimental Medicine, 190 (7), pp. 895-902. DOI: 10.1084/jem.190.7.895

Lou, Y., Lloyd, C., Gutierrez-Ramos, J.-C., Dorf, M.E. Chemokine amplification in mesangial cells (1999) Journal of Immunology, 163 (7), pp. 3985-3992.

Gonzalo, J.-A., Pan, Y., Lloyd, C.M., Jia, G.-Q., Yu, G., Dussault, B., Powers, C.A., Proudfoot, A.E.I., Coyle, A.J., Gearing, D., Gutierrez-Ramos, J.-C. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation (1999) Journal of Immunology, 163 (1), pp. 403-411.

Gerwin, N., Gonzalo, J.-A., Lloyd, C., Coyle, A.J., Reiss, Y., Banu, N., Wang, B., Hong, X., Avraham, H., Engelhardt, B., Springer, T.A., Gutierrez-Ramos, J.C. Prolonged eosinophil accumulation in allergic lung interstitium of ICAM- 2-deficient mice results in extended hyperresponsiveness (1999) Immunity, 10 (1), pp. 9-19. DOI: 10.1016/S1074-7613(00)80002-3

1998

Gonzalo, J.-A., Lloyd, C.M., Wen, D., Albar, J.P., Wells, T.N.C., Proudfoot, A., Martinez-A, C., Dorf, M., Bjerke, T., Coyle, A.J., Gutierrez-Ramos, J.-C. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness (1998) Journal of Experimental Medicine, 188 (1), pp. 157-167. DOI: 10.1084/jem.188.1.157

Lloyd, C., Gutierrez-Ramos, J.-C.The role of chemokines in tissue inflammation and autoimmunity in renal diseases (1998) Current Opinion in Nephrology and Hypertension, 7 (3), pp. 281-287.

Peled, A., Gonzalo, J.A., Lloyd, C., Gutierrez-Ramos, J.-C. The chemotactic cytokine Eotaxin acts as a granulocyte-macrophage colony-stimulating factor during lung inflammation (1998) Blood, 91 (6), pp. 1909-1916.

1997

Lloyd, C.M., Dorf, M.E., Proudfoot, A., Salant, D.J., Gutierrez-Ramos, J.-C. Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritis (1997) Journal of Leukocyte Biology, 62 (5), pp. 676-680.

Lloyd, C.M., Gonzalo, J.-A., Salant, D.J., Just, J., Gutierrez-Ramos, J.-C. Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus (1997) Journal of Clinical Investigation, 100 (5), pp. 963-971. DOI: 10.1172/JCI119647

Pan, Y., Lloyd, C., Zhou, H., Dolich, S., Deeds, J., Gonzalo, J.-A., Vath, J., Gosselin, M., Ma, J., Dussault, B., Woolf, E., Alperin, G., Culpepper, J., Gutierrez-Ramos, J.C., Gearing, D. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation (1997) Nature, 387 (6633), pp. 611-617. DOI: 10.1038/42491

Lloyd, C.M., Minto, A.W., Dorf, M.E., Proudfoot, A., Wells, T.N.C., Salant, D.J., Gutierrez-Ramos, J.-C. RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis(1997) Journal of Experimental Medicine, 185 (7), pp. 1371-1380. DOI: 10.1084/jem.185.7.1371

1996

Gonzalo, J.-A., Lloyd, C.M., Kremer, L., Finger, E., Martinez-A., C., Siegelman, M.H., Cybulsky, M., Gutierrez-Ramos, J.-C. Eosinophil recruitment to the lung in a murine model of allergic inflammation: The role of T cells, chemokines, and adhesion receptors (1996) Journal of Clinical Investigation, 98 (10), pp. 2332-2345. DOI: 10.1172/JCI119045

Jia, G.-Q., Gonzalo, J.A., Lloyd, C., Kremer, L., Lu, L., Martinez-A, C., Wershil, B.K., Gutierrez-Ramos, J.C. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation(1996) Journal of Experimental Medicine, 184 (5), pp. 1939-1951. DOI: 10.1084/jem.184.5.1939

1995

Andrews, P.A., Finn, J.E., Lloyd, C.M., Zhou, W., Mathieson, P.W., Sacks, S.H. Expression and tissue localization of donor‐specific complement C3 synthesized in human renal allografts(1995) European Journal of Immunology, 25 (4), pp. 1087-1093. DOI: 10.1002/eji.1830250434

1994

Andrews, P.A., Lloyd, C.M., Webb, M.C., Sacks, S.H. Acute interstitial nephritis associated with mycoplasma pneumoniae infection (1994) Nephrology Dialysis Transplantation, 9 (5), pp. 564-566. DOI: 10.1093/ndt/9.5.564

Lloyd, C.M., Collins, I., Belcher, A.J., Manuelpillai, N., Wozencraft, A.O., Staines, N.A. Characterization and pathological significance of monoclonal DNA-binding antibodies from mice with experimental malaria infection (1994) Infection and Immunity, 62 (5), pp. 1982-1988.

1993

Lloyd, C.M., Wozencraft, A.O., Williams, D.G. Cell-mediated pathology during murine malaria-associated nephritis (1993) Clinical and Experimental Immunology, 94 (3), pp. 398-402.

1990

Wozencraft, A.O., Lloyd, C.M., Staines, M.A., Griffiths, V.J. Role of DNA-binding antibodies in kidney pathology associated with murine malaria infections (1990) Infection and Immunity, 58 (7), pp. 2156-2164.

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